CHI3L1 Antikörper (AA 103-383)

Produktnummer ABIN7599648

Dieses Anti-CHI3L1-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von CHI3L1 in WB, ICC, ELISA und IF. Geeignet für Human, Maus und Ratte.

Kurzübersicht für CHI3L1 Antikörper (AA 103-383) (ABIN7599648)

Target: CHI3L1 (Chitinase 3-Like 1 (Cartilage Glycoprotein-39) (CHI3L1))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CHI3L1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunocytochemistry (ICC), ELISA, Immunofluorescence (IF)

Produktdetails anti-CHI3L1 Antikörper

Bindungsspezifität: AA 103-383

Verwendungszweck: Anti-YKL-40/CHI3L1 Antibody Picoband®

Kreuzreaktivität (Details): No cross-reactivity with other proteins.

Produktmerkmale: Anti-YKL-40/CHI3L1 Antibody Picoband® (ABIN7599648). Tested in ELISA, IF, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived human YKL-40/CHI3L1 recombinant protein (Position: S103-T383).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western blot, 0.25-0.5 μg/mL, Human, Mouse, Rat
Immunocytochemistry/Immunofluorescence, 5 μg/mL, Human
ELISA, 0.1-0.5 μg/mL, -
1. Chung, C., Tallerico, T., Seeman, P. Schizophrenia hippocampus has elevated expression of chondrex glycoprotein gene. Synapse 50: 29-34, 2003. 2. Hakala, B. E., White, C., Recklies, A. D. Human cartilage gp-39, a major secretory product of articular chondrocytes and synovial cells, is a mammalian member of a chitinase protein family. J. Biol. Chem. 268: 25803-25810, 1993. 3. Ober, C., Tan, Z., Sun, Y., Possick, J. D., Pan, L., Nicolae, R., Radford, S., Parry, R. R., Heinzmann, A., Deichmann, K. A., Lester, L. A., Gern, J. E., Lemanske, R. F., Jr., Nicolae, D. L., Elias, J. A., Chupp, G. L. Effect of variation in CHI3L1 on serum YKL-40 level, risk of asthma, and lung function. New Eng. J. Med. 358: 1682-1691, 2008.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Details zu CHI3L1

Target: CHI3L1 (Chitinase 3-Like 1 (Cartilage Glycoprotein-39) (CHI3L1))

Andere Bezeichnung: CHI3L1

Hintergrund:

Synonyms: Chitinase-3-like protein 1, BRP39 protein, Breast regression protein 39, Cartilage glycoprotein 39, CGP-39, GP-39, Chi3l1, Brp39, Chil1,

Tissue Specificity: Detected in lung in pulmonary macrophages and alveolar type 2 cells and in bronchoalveolar lavage (BAL) fluids. Expressed in mammary tumor cells (at protein level). Expressed in lung. Not detected in non-inflammatory colon.

Background: Chitinase-3-like protein 1 (CHI3L1), also known as YKL-40, is a secreted glycoprotein that is approximately 40 kDa in size that in humans is encoded by the CHI3L1 gene. Chitinases catalyze the hydrolysis of chitin, which is an abundant glycopolymer found in insect exoskeletons and fungal cell walls. The glycoside hydrolase 18 family of chitinases includes eight human family members. This gene encodes a glycoprotein member of the glycosyl hydrolase 18 family. The protein lacks chitinase activity and is secreted by activated macrophages, chondrocytes, neutrophils and synovial cells. The protein is thought to play a role in the process of inflammation and tissue remodeling.

Molekulargewicht: 43 kDa

Gen-ID: 1116

UniProt: P36222