DTNBP1 Antikörper (AA 1-351)

Produktnummer ABIN7599300

Dieses Anti-DTNBP1-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von DTNBP1 in WB, ELISA und FACS. Geeignet für Human, Maus und Ratte.

Kurzübersicht für DTNBP1 Antikörper (AA 1-351) (ABIN7599300)

Target: DTNBP1 (Dystrobrevin Binding Protein 1 (DTNBP1))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DTNBP1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Produktdetails anti-DTNBP1 Antikörper

Bindungsspezifität: AA 1-351

Verwendungszweck: Anti-Dysbindin/DTNBP1 Antibody Picoband®

Kreuzreaktivität (Details): No cross-reactivity with other proteins

Produktmerkmale: Anti-Dysbindin/DTNBP1 Antibody Picoband® (ABIN7599300). Tested in WB, Flow Cytometry, ELISA applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived human Dysbindin/DTNBP1 recombinant protein (Position: M1-S351). Human Dysbindin/DTNBP1 shares 79.4% and 78.6% amino acid (aa) sequence identity with mouse and rat Dysbindin/DTNBP1, respectively.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western blot, 0.25-0.5 μg/mL, Human, Mouse, Rat
Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human
ELISA, 0.1-0.5 μg/mL
1. Benson, M. A., Newey, S. E., Martin-Rendon, E., Hawkes, R., Blake, D. J. Dysbindin, a novel coiled-coil-containing protein that interacts with the dystrobrevins in muscle and brain. J. Biol. Chem. 276: 24232-24241, 2001. 2. Bryan, M. M., Tolman, N. J., Simon, K. L., Huizing, M., Hufnagel, R. B., Brooks, B. P., Speransky, V., Mullikin, J. C., Gahl, W. A., Malicdan, M. C. V., Gochuico, B. R. Clinical and molecular phenotyping of a child with Hermansky-Pudlak syndrome-7, an uncommon genetic type of HPS. Molec. Genet. Metab. 120: 378-383, 2017. 3. Dickman, D. K., Davis, G. W. The schizophrenia susceptibility gene dysbindin controls synaptic homeostasis. Science 326: 1127-1130, 2009.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Details zu DTNBP1

Target: DTNBP1 (Dystrobrevin Binding Protein 1 (DTNBP1))

Andere Bezeichnung: DTNBP1

Hintergrund:

Synonyms: DTNBP1, BLOC1S8, My031, Dysbindin, Biogenesis of lysosome-related organelles complex 1 subunit 8, BLOC-1 subunit 8, Dysbindin-1, Dystrobrevin-binding protein 1, Hermansky-Pudlak syndrome 7 protein, HPS7 protein

Background: This gene encodes a protein that may play a role in organelle biogenesis associated with melanosomes, platelet dense granules, and lysosomes. A similar protein in mouse is a component of a protein complex termed biogenesis of lysosome-related organelles complex 1 (BLOC-1), and binds to alpha- and beta-dystrobrevins, which are components of the dystrophin-associated protein complex (DPC). Mutations in this gene are associated with Hermansky-Pudlak syndrome type 7. This gene may also be associated with schizophrenia. Multiple transcript variants encoding distinct isoforms have been identified for this gene.

Molekulargewicht: 50 kDa

Gen-ID: 84062

Pathways: Synaptic Membrane, Regulation of G-Protein Coupled Receptor Protein Signaling