DTNBP1 Antikörper (AA 258-351)

Produktnummer ABIN7150910

Produktdetails anti-DTNBP1 Antikörper

Target: DTNBP1 (Dystrobrevin Binding Protein 1 (DTNBP1))

Bindungsspezifität: AA 258-351

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DTNBP1 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Dysbindin protein (258-351AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: IHC:1:200-1:500, IF:1:50-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu DTNBP1

Target: DTNBP1 (Dystrobrevin Binding Protein 1 (DTNBP1))

Andere Bezeichnung: DTNBP1 (DTNBP1 Produkte)

Synonyme: 5430437B18Rik antikoerper, AW048963 antikoerper, Bloc1s8 antikoerper, dysbindin antikoerper, sdy antikoerper, BLOC1S8 antikoerper, DBND antikoerper, HPS7 antikoerper, My031 antikoerper, SDY antikoerper, dtnbp1 antikoerper, zgc:56462 antikoerper, MGC83903 antikoerper, dbnd antikoerper, hps7 antikoerper, my031 antikoerper, MGC85477 antikoerper, DTNBP1 antikoerper, CG6856 antikoerper, Ddysb antikoerper, Dmel\\CG6856 antikoerper, si:ch211-285p6.1 antikoerper, dystrobrevin binding protein 1 antikoerper, Dysbindin antikoerper, dystrobrevin binding protein 1a antikoerper, dystrobrevin binding protein 1 L homeolog antikoerper, dystrobrevin binding protein 1 S homeolog antikoerper, dystrobrevin binding protein 1b antikoerper, Dtnbp1 antikoerper, DTNBP1 antikoerper, dtbp1 antikoerper, dtnbp1a antikoerper, dtnbp1.L antikoerper, dtnbp1.S antikoerper, dtnbp1 antikoerper, Dysb antikoerper, dtnbp1b antikoerper

Hintergrund:

Background: Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Associates with the BLOC-2 complex to facilitate the transport of TYRP1 independent of AP-3 function. Plays a role in synaptic vesicle trafficking and in neurotransmitter release. Plays a role in the regulation of cell surface exposure of DRD2. May play a role in actin cytoskeleton reorganization and neurite outgrowth. May modulate MAPK8 phosphorylation. Appears to promote neuronal transmission and viability through regulating the expression of SNAP25 and SYN1, modulating PI3-kinase-Akt signaling and influencing glutamatergic release. Regulates the expression of SYN1 through binding to its promoter. Modulates prefrontal cortical activity via the dopamine/D2 pathway.

Aliases: DTBP1_HUMAN antibody, DTNBP1 antibody, Dysbindin antibody, Dysbindin-1 antibody, Dystrobrevin binding protein 1 antibody, Dystrobrevin-binding protein 1 antibody, Hermansky Pudlak syndrome 7 protein antibody, Hermansky-Pudlak syndrome 7 protein antibody, HPS7 antibody, HPS7 protein antibody

UniProt: Q96EV8

Pathways: Synaptic Membrane, Regulation of G-Protein Coupled Receptor Protein Signaling