TYMS Antikörper (AA 1-313)

Produktnummer ABIN7599260

Der Kaninchen Polyklonal Anti-TYMS-Antikörper wurde für WB, IF, IHC und ELISA validiert. Er ist geeignet, TYMS in Proben von Human, Ratte und Affe zu detektieren.

Kurzübersicht für TYMS Antikörper (AA 1-313) (ABIN7599260)

Target: TYMS (Thymidylate Synthetase (TYMS))

Reaktivität: Human, Ratte, Affe

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TYMS Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (IHC), ELISA

Produktdetails anti-TYMS Antikörper

Bindungsspezifität: AA 1-313

Verwendungszweck: Anti-Thymidylate Synthase/TYMS Antibody Picoband®

Kreuzreaktivität (Details): No cross-reactivity with other proteins.

Produktmerkmale: Anti-Thymidylate Synthase/TYMS Antibody Picoband® (ABIN7599260). Tested in ELISA, IF, IHC, WB applications. This antibody reacts with Human, Monkey, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived human Thymidylate Synthase/TYMS recombinant protein (Position: M1-V313).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western blot, 0.25-0.5 μg/mL, Human, Monkey
Immunohistochemistry(Paraffin-embedded Section), 2-5 μg/mL, Human, Rat
Immunofluorescence, 5 μg/mL, Human
ELISA, 0.1-0.5 μg/mL, -
1. Chu, J., Dolnick, B. J. Natural antisense (rTS-alpha) RNA induces site-specific cleavage of thymidylate synthase mRNA. Biochim. Biophys. Acta 1587: 183-193, 2002. 2. Hori, T., Ayusawa, D., Shimizu, K., Koyama, H., Seno, T. Assignment of human gene encoding thymidylate synthase to chromosome 18 using interspecific cell hybrids between thymidylate synthase-negative mouse mutant cells and human diploid fibroblasts. Somat. Cell Molec. Genet. 11: 277-283, 1985. 3. Hori, T., Ayusawa, D., Shimizu, K., Koyama, H., Seno, T. Assignment of the human TMS gene, encoding thymidylate synthase, to chromosome 18. (Abstract) Cytogenet. Cell Genet. 40: 654-655, 1985.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Details zu TYMS

Target: TYMS (Thymidylate Synthetase (TYMS))

Andere Bezeichnung: TYMS

Hintergrund:

Synonyms: Interleukin-3 receptor subunit alpha, IL-3 receptor subunit alpha, IL-3R subunit alpha, IL-3R-alpha, IL-3RA, CD123, IL3RA, IL3R

Tissue Specificity: Brain.

Background: Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using, 10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occurring antisense transcript, mitochondrial enolase superfamily member 1 (GeneID:55556), vary inversely when cell-growth progresses from late-log to plateau phase. Polymorphisms in this gene may be associated with etiology of neoplasia, including breast cancer, and response to chemotherapy.

Molekulargewicht: 36 kDa

Gen-ID: 7298

UniProt: P04818

Pathways: Mitotic G1-G1/S Phases