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Rekombinanter TYMS Antikörper (AA 60-174)

TYMS Reaktivität: Human IF, FACS, ELISA, RIA, Coat Wirt: Maus Monoclonal rTYMS-1884 unconjugated Recombinant Antibody
Produktnummer ABIN6940823
  • Target Alle TYMS Antikörper anzeigen
    TYMS (Thymidylate Synthetase (TYMS))
    Antikörpertyp
    Recombinant Antibody
    Bindungsspezifität
    • 15
    • 11
    • 5
    • 5
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 60-174
    Reaktivität
    • 91
    • 28
    • 13
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Human
    Wirt
    • 49
    • 40
    • 2
    Maus
    Klonalität
    • 47
    • 44
    Monoklonal
    Konjugat
    • 45
    • 7
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser TYMS Antikörper ist unkonjugiert
    Applikation
    • 51
    • 41
    • 34
    • 21
    • 19
    • 19
    • 19
    • 17
    • 14
    • 13
    • 11
    • 7
    • 6
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    Immunofluorescence (IF), Flow Cytometry (FACS), ELISA, Radioimmunoassay (RIA), Coating (Coat)
    Spezifität
    It recognizes a protein of 36 kDa, identified as Thymidylate Synthase (TS) (EC 2.1.1.45). It converts deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), which is essential for DNA biosynthesis. TS is also a critical target for the fluoropyrimidines, an important group of antineoplastic drugs that are widely used in the treatment of solid tumors. Both 5-FU and fluorodeoxyuridine are converted in tumor cells to FdUMP which inactivates TS by formation of a ternary covalent complex in the presence of the folate cofactor 5,10-methylenetetrahydrofolate. Expression of TS protein has been reported to associate with response to 5-fluorouracil (5-FU) in human colorectal, gastric, head and neck, and breast carcinomas.
    Aufreinigung
    Purified by Protein A/G
    Immunogen
    Recombinant human thymidylate synthase protein fragment (around aa 60-174) (exact sequence is proprietary)
    Klon
    RTYMS-1884
    Isotyp
    IgG1 kappa
    Top Product
    Discover our top product TYMS Primärantikörper
  • Applikationshinweise

    Positive Control: MOLT4, Ramos, 5-FU-resistant colon carcinoma cell lines (NCI H630R10, NCI H630R1), 5-FU-resistant breast cancer cell lines, MCF-Ad5 and MCF-Ad10. Testicular carcinomas.

    Known Application: ELISA (For coating, order antibody without BSA), Flow Cytometry (0.5-1 μg/million cells), Immunofluorescence (0.5-1 μg/mL), Optimal dilution for a specific application should be determined.

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    200 μg/mL
    Buffer
    10 mM PBS with 0.05 % BSA & 0.05 % azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C
    Informationen zur Lagerung
    Antibody with azide - store at 2 to 8°C. Antibody is stable for 24 months. ,Non-hazardous. No MSDS required.
    Haltbarkeit
    24 months
  • Target
    TYMS (Thymidylate Synthetase (TYMS))
    Andere Bezeichnung
    TYMS (TYMS Produkte)
    Synonyme
    FN1 antikoerper, ECK2823 antikoerper, JW2795 antikoerper, ts antikoerper, Ts antikoerper, HST422 antikoerper, TMS antikoerper, TS antikoerper, thymidylate synthetase antikoerper, contains intron in T4 phage antikoerper, ThyE antikoerper, thymidylate synthase antikoerper, thymidylate synthetase L homeolog antikoerper, TYMS antikoerper, thyA antikoerper, td antikoerper, thyE antikoerper, DDA3937_RS04960 antikoerper, tyms.L antikoerper, XBJ1_RS15770 antikoerper, EAMY_RS20680 antikoerper, Tyms antikoerper
    Substanzklasse
    Viral Protein
    Molekulargewicht
    36kDa
    Gen-ID
    7298
    UniProt
    P04818
    Pathways
    Mitotic G1-G1/S Phases
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