DOCK8 Antikörper (AA 1-2099)

Produktnummer ABIN7599085

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch DOCK8 in WB, IHC, ELISA und FACS. Er zeigt eine Reaktivität gegenüber Human, Maus und Ratte.

Kurzübersicht für DOCK8 Antikörper (AA 1-2099) (ABIN7599085)

Target: DOCK8 (Dedicator of Cytokinesis 8 (DOCK8))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DOCK8 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Flow Cytometry (FACS)

Produktdetails anti-DOCK8 Antikörper

Bindungsspezifität: AA 1-2099

Verwendungszweck: Anti-DOCK8 Antibody Picoband®

Kreuzreaktivität (Details): No cross-reactivity with other proteins

Produktmerkmale: Anti-DOCK8 Antibody Picoband® (ABIN7599085). Tested in WB, IHC, Flow Cytometry, ELISA applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived human DOCK8 recombinant protein (Position: M1-S2099). Human DOCK8 shares 91.8% amino acid (aa) sequence identity with mouse DOCK8.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western blot, 0.25-0.5 μg/mL, Rat
Immunohistochemistry, 2-5 μg/mL, Human, Mouse
Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human
ELISA, 0.1-0.5 μg/mL
1. Griggs, B. L., Ladd, S., Saul, R. A., DuPont, B. R., Srivastava, A. K. Dedicator of cytokinesis 8 is disrupted in two patients with mental retardation and developmental disabilities. Genomics 91: 195-202, 2008. 2. MacDermot, K. D., Hulten, M. Female with hypohidrotic ectodermal dysplasia and de novo (X,9) translocation: clinical documentation of the AnLy cell line case. Hum. Genet. 84: 577-579, 1990. 3. Pillay, B. A., Fusaro, M., Gray, P. E., Statham, A. L., Burnett, L., Bezrodnik, L., Kane, A., Tong, W., Abdo, C., Winter, S., Chevalier, S., Levy, R., and 18 others. Somatic reversion of pathogenic DOCK8 variants alters lymphocyte differentiation and function to effectively cure DOCK8 deficiency. J. Clin. Invest. 131: e142434, 2021.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Details zu DOCK8

Target: DOCK8 (Dedicator of Cytokinesis 8 (DOCK8))

Andere Bezeichnung: DOCK8

Hintergrund:

Synonyms: DOCK8, Dedicator of cytokinesis protein 8

Background: This gene encodes a member of the DOCK180 family of guanine nucleotide exchange factors. Guanine nucleotide exchange factors interact with Rho GTPases and are components of intracellular signaling networks. Mutations in this gene result in the autosomal recessive form of the hyper-IgE syndrome. Alternatively spliced transcript variants encoding different isoforms have been described.

Molekulargewicht: 230 kDa

Gen-ID: 81704