NLRP7 Antikörper (AA 1-169)

Produktnummer ABIN7599027

Dieses Anti-NLRP7-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von NLRP7 in ELISA, IHC, WB und FACS. Geeignet für Human.

Kurzübersicht für NLRP7 Antikörper (AA 1-169) (ABIN7599027)

Target: NLRP7 (NLR Family, Pyrin Domain Containing 7 (NLRP7))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NLRP7 Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (IHC), Western Blotting (WB), Flow Cytometry (FACS)

Produktdetails anti-NLRP7 Antikörper

Bindungsspezifität: AA 1-169

Verwendungszweck: Anti-NLRP7 Antibody Picoband®

Kreuzreaktivität (Details): No cross-reactivity with other proteins.

Produktmerkmale: Anti-NLRP7 Antibody Picoband® (ABIN7599027). Tested in ELISA, Flow Cytometry, IHC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived human NLRP7 recombinant protein (Position: M1-L169).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western blot, 0.25-0.5 μg/mL, Human
Immunohistochemistry(Paraffin-embedded Section), 2-5 μg/mL, Human
Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human
ELISA, 0.1-0.5 μg/mL, -
1. Agarwal, P., Bagga, R., Jain, V., Kalra, J., Gopalan, S. Familial recurrent molar pregnancy: a case report. Acta Obstet. Gynecol. Scand. 83: 213-214, 2004. 2. Aghajanova, L., Mahadevan, S., Altmae, S., Stravreus-Evers, A., Regan, L., Sebire, N., Dixon, P., Fisher, R. A., Van den Veyver, I. B. No evidence for mutations in NLRP7, NLRP2 or KHDC3L in women with unexplained recurrent pregnancy loss or infertility. Hum. Reprod. 30: 232-238, 2015. 3. Andreasen, L., Bolund, L., Niemann, I., Hansen, E. S., Sunde, L. Mosaic moles and non-familial biparental moles are not caused by mutation in NLRP7, NLRP2 or C6orf221. Molec. Hum. Reprod. 18: 593-598, 2012.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Details zu NLRP7

Target: NLRP7 (NLR Family, Pyrin Domain Containing 7 (NLRP7))

Andere Bezeichnung: NLRP7

Hintergrund:

Synonyms: Protein SOX-15, Protein SOX-12, Protein SOX-20, SOX15, SOX12, SOX20, SOX26, SOX27

Tissue Specificity: Widely expressed in fetal and adult tissues examined, highest level found in fetal spinal cord and adult brain and testis.

Background: NACHT, LRR and PYD domains-containing protein 7 is a protein that in humans is encoded by the NLRP7 gene. This gene encodes a member of the NACHT, leucine rich repeat, and PYD containing (NLRP) protein family. It has an N-terminal pyrin domain, followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. NLRP proteins are implicated in the activation of proinflammatory caspases through multiprotein complexes called inflammasomes. This gene may act as a feedback regulator of caspase-1-dependent interleukin 1-beta secretion. Alternative splicing results in multiple transcript variants encoding different isoforms.

Molekulargewicht: 112 kDa

Gen-ID: 199713

Pathways: Inflammasome