Telefon:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@antikoerper-online.de

SIGMAR1 Antikörper (AA 1-154)

Dieses Anti-SIGMAR1-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von SIGMAR1 in WB, IHC und ELISA. Geeignet für Human, Maus, Ratte und Affe.
Produktnummer ABIN7599011

Kurzübersicht für SIGMAR1 Antikörper (AA 1-154) (ABIN7599011)

Target

Alle SIGMAR1 Antikörper anzeigen
SIGMAR1 (sigma Non-Opioid Intracellular Receptor 1 (SIGMAR1))

Reaktivität

Human, Maus, Ratte, Affe

Wirt

  • 20
Kaninchen

Klonalität

  • 20
Polyklonal

Konjugat

  • 9
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser SIGMAR1 Antikörper ist unkonjugiert

Applikation

  • 8
  • 6
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Western Blotting (WB), Immunohistochemistry (IHC), ELISA
  • Bindungsspezifität

    • 5
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1-154

    Verwendungszweck

    Anti-Sigma1-receptor/SIGMAR1 Antibody Picoband®

    Kreuzreaktivität (Details)

    No cross-reactivity with other proteins

    Produktmerkmale

    Anti-Sigma1-receptor/SIGMAR1 Antibody Picoband® (ABIN7599011). Tested in ELISA, IHC, WB applications. This antibody reacts with Human, Monkey, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

    Aufreinigung

    Immunogen affinity purified.

    Immunogen

    E.coli-derived human Sigma1-receptor/SIGMAR1 recombinant protein (Position: G1-H154).

    Isotyp

    IgG
  • Applikationshinweise

    Western blot, 0.1-0.25 μg/mL, Human, Monkey, Mouse
    Immunohistochemistry(Paraffin-embedded Section), 2-5 μg/mL, Human, Mouse, Rat
    ELISA, 0.1-0.5 μg/mL, -
    1. Al-Saif, A., Al-Mohanna, F., Bohlega, S. A mutation in sigma-1 receptor causes juvenile amyotrophic lateral sclerosis. Ann. Neurol. 70: 913-919, 2011. 2. Aydar, E., Palmer, C. P., Klyachko, V. A., Jackson, M. B. The sigma receptor as a ligand-regulated auxiliary potassium channel subunit. Neuron 34: 399-410, 2002. 3. Belzil, V. V., Daoud, H., Camu, W., Strong, M. J., Dion, P. A., Rouleau, G. A. Genetic analysis of SIGMAR1 as a cause of familial ALS with dementia. Europ. J. Hum. Genet. 21: 237-239, 2013.

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Lyophilized

    Rekonstitution

    Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

    Konzentration

    500 μg/mL

    Buffer

    Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.
  • Target

    SIGMAR1 (sigma Non-Opioid Intracellular Receptor 1 (SIGMAR1))

    Andere Bezeichnung

    SIGMAR1

    Hintergrund

    Synonyms: Heat shock protein beta-8,HspB8,Alpha-crystallin C chain,E2-induced gene 1 protein,Protein kinase H11,Small stress protein-like protein HSP22,HSPB8,CRYAC, E2IG1, HSP22,PP1629,

    Tissue Specificity: Predominantly expressed in skeletal muscle and heart. .

    Background: The sigma-1 receptor (σ1R), one of two sigma receptor subtypes, is a chaperone protein at the endoplasmic reticulum (ER) that modulates calcium signaling through the IP3 receptor. In humans, the σ1 receptor is encoded by the SIGMAR1 gene. This gene encodes a receptor protein that interacts with a variety of psychotomimetic drugs, including cocaine and amphetamines. The receptor is believed to play an important role in the cellular functions of various tissues associated with the endocrine, immune, and nervous systems. As indicated by its previous name, opioid receptor sigma 1 (OPRS1), the product of this gene was erroneously thought to function as an opioid receptor, it is now thought to be a non-opioid receptor. Mutations in this gene has been associated with juvenile amyotrophic lateral sclerosis 16. Alternative splicing of this gene results in transcript variants encoding distinct isoforms.

    Molekulargewicht

    25 kDa

    Gen-ID

    10280

    UniProt

    Q99720

    Pathways

    SARS-CoV-2 Protein Interaktom
Sie sind hier:
Chat with us!