ADAR Antikörper (AA 1-1152)

Produktnummer ABIN7598956

Der Kaninchen Polyklonal Anti-ADAR-Antikörper wurde für WB, IHC, ELISA, IF und ICC validiert. Er ist geeignet, ADAR in Proben von Human, Maus und Ratte zu detektieren.

Kurzübersicht für ADAR Antikörper (AA 1-1152) (ABIN7598956)

Target: ADAR (Adenosine Deaminase, RNA-Specific (ADAR))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ADAR Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Produktdetails anti-ADAR Antikörper

Bindungsspezifität: AA 1-1152

Verwendungszweck: Anti-ADAR1/ADAR Antibody Picoband®

Kreuzreaktivität (Details): No cross-reactivity with other proteins.

Produktmerkmale: Anti-ADAR1/ADAR Antibody Picoband® (ABIN7598956). Tested in ELISA, IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived human ADAR1/ADAR recombinant protein (Position: M1-E1152).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western blot, 0.25-0.5 μg/mL, Human
Immunohistochemistry(Paraffin-embedded Section), 2-5 μg/mL, Human, Mouse, Rat
Immunocytochemistry/Immunofluorescence, 5 μg/mL, Human
ELISA, 0.1-0.5 μg/mL, -
1. Agranat, L., Raitskin, O., Sperling, J., Sperling, R. The editing enzyme ADAR1 and the mRNA surveillance protein hUpf1 interact in the cell nucleus. Proc. Nat. Acad. Sci. 105: 5028-5033, 2008. 2. Bass, B. L., Weintraub, H. An unwinding activity that covalently modifies its double-stranded RNA substrate. Cell 55: 1089-1098, 1988. 3. Chao, S.-C., Huang, C.-Y., Yang, M.-H. A novel nonsense mutation of the DSRAD gene in a Taiwanese family with dyschromatosis symmetrica hereditaria. Europ. J. Derm. 16: 449-540, 2006.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Details zu ADAR

Target: ADAR (Adenosine Deaminase, RNA-Specific (ADAR))

Andere Bezeichnung: ADAR

Hintergrund:

Synonyms: Tumor necrosis factor receptor superfamily member 9, 4-1BB ligand receptor, T-cell antigen 4-1BB, CD137, Tnfrsf9, Cd137, Ila, Ly63

Tissue Specificity: Expressed on the surface of activated T-cells.

Background: Double-stranded RNA-specific adenosine deaminase is an enzyme that in humans is encoded by the ADAR gene. This gene encodes the enzyme responsible for RNA editing by site-specific deamination of adenosines. This enzyme destabilizes double-stranded RNA through conversion of adenosine to inosine. Mutations in this gene have been associated with dyschromatosis symmetrica hereditaria. Alternative splicing results in multiple transcript variants.

Molekulargewicht: 110 kDa

Gen-ID: 103

UniProt: P55265

Pathways: Protein targeting to Nucleus