SHANK1 Antikörper (AA 469-691) (FL650)

Produktnummer ABIN7595850

Der Maus Monoklonal Anti-SHANK1-Antikörper wurde für IHC und ICC validiert. Er ist geeignet, SHANK1 in Proben von Ratte zu detektieren.

Kurzübersicht für SHANK1 Antikörper (AA 469-691) (FL650) (ABIN7595850)

Target: SHANK1 (SH3 and Multiple Ankyrin Repeat Domains 1 (SHANK1))

Reaktivität: Ratte

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser SHANK1 Antikörper ist konjugiert mit FL650

Applikation: Immunohistochemistry (IHC), Immunocytochemistry (ICC)

Klon: N22-21

Produktdetails anti-SHANK1 Antikörper (FL650)

Bindungsspezifität: AA 469-691

Verwendungszweck: Anti-Shank1 Antibody FL650 Conjugate

Spezifität: No off-targets reported for Shank2 or Shank3

Kreuzreaktivität: Human, Maus, Ratte

Produktmerkmale: Our Anti-Shank1 mouse monoclonal primary antibody is produced in-house from hybridoma clone N22/21. It detects human, mouse, and rat Shank1, and is purified by Protein A chromatography. It is great for use in IHC, ICC.

Aufreinigung: Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and conjugation of purified mAb.

Reinheit: > 90 % specific antibody

Immunogen: Fusion protein amino acids 469-691 (SH3/PDZ domains) of rat Shank1 (accession number Q9WV48) produced recombinantly in E. Coli

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: PBS with 0.09 % azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Haltbarkeit: 12 months

Details zu SHANK1

Target: SHANK1 (SH3 and Multiple Ankyrin Repeat Domains 1 (SHANK1))

Andere Bezeichnung: Shank1

Hintergrund:

Synonyms: SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (GKAP/SAPAP-interacting protein) (SPANK-1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP) (Synamon)

Target Description: SH3 and multiple ankyrin repeat domains protein 1, or shank 1 is a member of the shank family. Shank 1 binding domains include a SH3 domain, a proline rich domain, a PDZ domain and ankyrin repeat domains. Unlike other shank family proteins, shank 1 is found in only in brain in the neuropil of cortex, CA1 region hippocampus and molecular layer of cerebellum, amygdala, substantia nigra and thalamus. Cellularly, shank 1 can be found in cytoplasm, cell junctions, postsynaptic cell membrane and postsynaptic density. Many isoforms of shank 1 exist, and some are expressed during development, while others are expressed in mature tissue. Shank 1 acts as a scaffold protein anchoring and connecting membrane bound receptors and other proteins to the cytoskeleton in neurons to enable cell signaling. In this manner, Shank 1 may play a role in synapse formation and dendritic spine maturation. Mutations in this gene have been associated with autism spectrm disorder and diabetic encephalopathy.

Gene Name Alternatives: Shank1

Molekulargewicht: 190-220 kDa (alternative splice variants)

Pathways: Synaptic Membrane, Maintenance of Protein Location