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SHANK1 Antikörper (AA 469-691) (FITC)

SHANK1 Reaktivität: Ratte WB, IHC, AA Wirt: Maus Monoclonal N22-21 (Formerly S22-21) FITC
Produktnummer ABIN2483710
  • Target Alle SHANK1 Antikörper anzeigen
    SHANK1 (SH3 and Multiple Ankyrin Repeat Domains 1 (SHANK1))
    Bindungsspezifität
    • 15
    • 12
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 469-691
    Reaktivität
    • 32
    • 18
    • 11
    • 2
    • 1
    • 1
    • 1
    • 1
    Ratte
    Wirt
    • 30
    • 17
    Maus
    Klonalität
    • 30
    • 17
    Monoklonal
    Konjugat
    • 17
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser SHANK1 Antikörper ist konjugiert mit FITC
    Applikation
    • 40
    • 17
    • 13
    • 13
    • 10
    • 6
    • 5
    • 5
    • 4
    • 3
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Antibody Array (AA)
    Spezifität
    Detects ~190-220 kDa (alternative splice variants). No cross-reactivity against Shank2 or Shank3.
    Kreuzreaktivität
    Human, Maus, Ratte
    Aufreinigung
    Protein G Purified
    Immunogen
    Fusion protein amino acids 469-691 (SH3/PDZ domains) of rat Shank1
    Klon
    N22-21 (Formerly S22-21)
    Isotyp
    IgG1
    Top Product
    Discover our top product SHANK1 Primärantikörper
  • Applikationshinweise
    • WB (1:1000)
    • IHC (1:1000)
    • ICC/IF (1:100)
    • optimal dilutions for assays should be determined by the user.
    Kommentare

    1 μg/ml of ABIN2483710 was sufficient for detection of Shank1 in 10 μg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    PBS pH 7.4, 50 % glycerol, 0.09 % sodium azide, Storage buffer may change when conjugated
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C
    Informationen zur Lagerung
    Conjugated antibodies should be stored at 4°C
  • Target
    SHANK1 (SH3 and Multiple Ankyrin Repeat Domains 1 (SHANK1))
    Andere Bezeichnung
    SHANK1 (SHANK1 Produkte)
    Synonyme
    SPANK-1 antikoerper, SSTRIP antikoerper, synamon antikoerper, Shank1a antikoerper, Spank1 antikoerper, Sstrip antikoerper, SH3 and multiple ankyrin repeat domains 1 antikoerper, SHANK1 antikoerper, Shank1 antikoerper
    Hintergrund
    Shank proteins make up a family of scaffold proteins identified through their interaction with a variety of membrane and cytoplasmic proteins (1). Shank proteins at postsynaptic sites of excitatory synapses play roles in signal transmission into the postsynaptic neuron. Studies suggest that Shank2 is expressed in the neurons of the developing retina, and could play a role in the neuronal differentiation of the developing retina (2). Other recent studies suggest that the disruption of glutamate receptors at the Shank postsynaptic platform could contribute to the destruction of the postsynaptic density, which underlies the synaptic dysfunction and loss in Alzheimer's disease (3).
    Gen-ID
    78957
    NCBI Accession
    NP_113939
    UniProt
    Q9WV48
    Pathways
    Synaptic Membrane, Maintenance of Protein Location
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