C3 Antikörper

Produktnummer ABIN7595376

Der Maus Monoklonal Anti-C3-Antikörper wurde für FACS und AGG validiert. Er ist geeignet, C3 in Proben von Human zu detektieren.

Kurzübersicht für C3 Antikörper (ABIN7595376)

Target: C3 (Complement Component 3 (C3))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser C3 Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS), Aggregation (AGG)

Klon: BGRL11

Produktdetails anti-C3 Antikörper

Verwendungszweck: Anti-Hu C3d Purified

Spezifität: The mouse monoclonal antibody BGRL11 recognizes human complement fragment C3d.

Aufreinigung: Purified by protein-A affinity chromatography.

Immunogen: intact human erythrocytes coated with C3/C4

Isotyp: IgM

Anwendungsinformationen

Applikationshinweise: Flow cytometry: Recommended dilution: 0.5-4 μg/mL.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 mg/mL

Buffer: Tris buffered saline (TBS), pH 8.0, 15 mM sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store at 2-8°C. Do not freeze.

Details zu C3

Target: C3 (Complement Component 3 (C3))

Andere Bezeichnung: C3d

Hintergrund: Complement component C3 plays a key role in the activation of complement system. In classical complement system pathway the activated C2 and C4 form classical C3-convertase (C4b2b) which cleaves C3 into C3a and C3b. In alternative complement system pathway C3 is cleaved by alternative C3-convertase (C3bBb), composed of C3b (which can be generated also by spontaneous hydrolysis of C3) and the activated form of factor B. C3b activates downstream cascade leading to formation of pores in the plasma membrane of attacked cell. C3b and its proteolytically inactive form iC3b also serve as important opsonins. C3b can generate C3f, as well as the iC3b can be further cleaved into C3c, C3d and C3g. Complement system is regulated by effective inactivation of free C3b by factor H and factor I. C3b attached to the surface of its target is protected from this inactivation. Complement system is also regulated by other proteins, e.g. CD35, CD46, CD55, or CD59. Undesired activation of complement cascade can lead to severe diseases such as PNH, rheumatoid arthritis, macular degeneration and other. Recently it has been demonstrated to take part in complications associated with Covid-19.

Gen-ID: 718

UniProt: P01024

Pathways: Komplementsystem, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Regulation of G-Protein Coupled Receptor Protein Signaling