TMPRSS2 Antikörper (AA 2-50)

Produktnummer ABIN7595311

Produktdetails anti-TMPRSS2 Antikörper

Target: TMPRSS2 (Transmembrane Protease, serine 2 (TMPRSS2))

Bindungsspezifität: AA 2-50

Reaktivität: Human

Wirt: Meerschweinchen

Klonalität: Polyklonal

Konjugat: Dieser TMPRSS2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Verwendungszweck: Guinea pig antibody to TMPRSS2

Spezifität: Specific for TMPRSS2.

Kreuzreaktivität: Human, Ratte

Kreuzreaktivität (Details): Other species not yet test.

Aufreinigung: Whole serum

Immunogen: A synthetic peptide from AA 2-50 of human TMPRSS2 conjugated to blue carrier protein was used as the antigen.

Anwendungsinformationen

Applikationshinweise: IHC WB. A dilution of 1: 2000 is recommended fro WB,IHC-P. The optimal dilution should be determined by the end user. Not yet tested in other applications.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8C for a shorter term. When reconstituting glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Haltbarkeit: 12 months

Details zu TMPRSS2

Target: TMPRSS2 (Transmembrane Protease, serine 2 (TMPRSS2))

Andere Bezeichnung: TMPRSS2 (TMPRSS2 Produkte)

Hintergrund: Function: Plasma membrane-anchored serine protease that participates in proteolytic cascades of relevance for the normal physiologic function of the prostate. Androgen-induced TMPRSS2 activates several substrates that include pro-hepatocyte growth factor/HGF the protease activated receptor-2/F2RL1 or matriptase/ST14 leading to extracellular matrix disruption and metastasis of prostate cancer cells. In addition activates trigeminal neurons and contribute to both spontaneous pain and mechanical allodynia. (Microbial infection) Facilitates human coronaviruses SARS-CoV and SARS-CoV-2 infections via two independent mechanisms proteolytic cleavage of ACE2 receptor which promotes viral uptake and cleavage of coronavirus spike glycoproteins which activates the glycoprotein for host cell entry. Proteolytically cleaves and activates the spike glycoproteins of human coronavirus 229E (HCoV-229E) and human coronavirus EMC (HCoV-EMC) and the fusion glycoproteins F0 of Sendai virus (SeV) human metapneumovirus (HMPV) human parainfluenza 1 2 3 4a and 4b viruses (HPIV). Essential for spread and pathogenesis of influenza A virus (strains H1N1 H3N2 and H7N9), involved in proteolytic cleavage and activation of hemagglutinin (HA) protein which is essential for viral infectivity. Expression: Expressed in several tissues that comprise large populations of epithelial cells with the highest level of transcripts measured in the prostate gland. Expressed in type II pneumocytes in the lung (at protein level). Expressed strongly in small intestine. Also expressed in colon stomach and salivary gland. Coexpressed with ACE2 within lung type II pneumocytes ileal absorptive enterocytes intestinal epithelial cells cornea gallbladder and nasal goblet secretory cells

Pathways: SARS-CoV-2 Protein Interaktom