HSP90AB1 Antikörper (AA 635-724)

Produktnummer ABIN725495

Der Kaninchen Polyklonal Anti-HSP90AB1-Antikörper wurde für WB, ELISA, FACS, IHC (p), IF (cc), IF (p) und IHC (fro) validiert. Er ist geeignet, HSP90AB1 in Proben von Human, Maus und Ratte zu detektieren. Es sind 3+ Publikationen verfügbar.

Kurzübersicht für HSP90AB1 Antikörper (AA 635-724) (ABIN725495)

Target: HSP90AB1 (Heat Shock Protein 90kDa alpha (Cytosolic), Class B Member 1 (HSP90AB1))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HSP90AB1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Produktdetails anti-HSP90AB1 Antikörper

Bindungsspezifität: AA 635-724

Kreuzreaktivität: Human, Maus, Ratte

Homologie: Dog,Cow,Pig,Chicken

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human HSP90 beta

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Referenzen für anti-HSP90AB1 Antikörper (ABIN725495)

Bozok Cetintas, Acikgoz, Yigitturk, Demir, Oktem, Tezcanli Kaymaz, Oltulu, Aktug: "Effects of flavopiridol on critical regulation pathways of CD133high/CD44high lung cancer stem cells." in: Medicine, Vol. 95, Issue 43, pp. e5150, (2016) (PubMed).

Mori, Akita, Tanida, Ishida, Toda, Inoue, Yashiro, Sawada, Hirakawa, Nakada et al.: "MUC1 protein induces urokinase-type plasminogen activator (uPA) by forming a complex with NF-κB p65 transcription factor and binding to the uPA promoter, leading to enhanced invasiveness of cancer ..." in: The Journal of biological chemistry, Vol. 289, Issue 51, pp. 35193-204, (2015) (PubMed).

Ding, Wu, Su, Zhou, Zhao, Deng, Zhang, Liu, Wang, Liu: "Expression of heat shock protein 90 genes during early development and infection in Megalobrama amblycephala and evidence for adaptive evolution in teleost." in: Developmental and comparative immunology, Vol. 41, Issue 4, pp. 683-93, (2013) (PubMed).

Details zu HSP90AB1

Target: HSP90AB1 (Heat Shock Protein 90kDa alpha (Cytosolic), Class B Member 1 (HSP90AB1))

Andere Bezeichnung: HSP90 beta

Hintergrund:

Synonyms: HSP84, HSPC2, HSPCB, D6S182, HSP9B, Heat shock protein HSP 9-beta, HSP 9, Heat shock 84 kDa, HSP 84, HSP9AB1

Background: Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.

Gen-ID: 3326

UniProt: P08238

Pathways: Regulation of Cell Size