Resistin Antikörper

Produktnummer ABIN7566444

Dieses Anti-Resistin-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von Resistin in ELISA. Geeignet für Human.

Kurzübersicht für Resistin Antikörper (ABIN7566444)

Target: Resistin (RETN)

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Resistin Antikörper ist unkonjugiert

Applikation: ELISA

Klon: HRES106

Produktdetails anti-Resistin Antikörper

Verwendungszweck: anti-Resistin (human), mAb (HRES106)

Produktmerkmale:

Monoclonal antibody. Recognizes human resistin. Does not cross-react with mouse resistin. Applications: ELISA. Isotype: Mouse IgG2akappa. Clone: HRES106. Liquid. In PBS containing 0.02 % sodium azide. The adipokine resistin which belongs to a family of cysteine-rich C-terminal proteins known as resistin-like molecules (RELM, RELMα/FIZZ 1 and RELMβ/FIZZ 2) of FIZZ (found in inflammatory zone) that are thought to be involved in inflammatory processes. Previous studies in mice showed that resistin impairs glucose tolerance and insulin action. In addition, resistin also inhibits adipogenesis in murine 3T3-L1 cells. Therefore resistin has also been proposed as an adipocyte-secreted factor thought to link obesity and T2DM. Resistin is secreted by obese subcutaneous adipose tissue and impaired myotube thickness and nuclear fusion by activation of the classical NF-κB pathway. In human, resistin levels are increased in the serum of obese individuals and resistin is used as a severity marker of asthma.

The adipokine resistin which belongs to a family of cysteine-rich C-terminal proteins known as resistin-like molecules (RELM, RELMalpha/FIZZ 1 and RELMbeta/FIZZ 2) of FIZZ (found in inflammatory zone) that are thought to be involved in inflammatory processes. Previous studies in mice showed that resistin impairs glucose tolerance and insulin action. In addition, resistin also inhibits adipogenesis in murine 3T3-L1 cells. Therefore resistin has also been proposed as an adipocyte-secreted factor thought to link obesity and T2DM. Resistin is secreted by obese subcutaneous adipose tissue and impaired myotube thickness and nuclear fusion by activation of the classical NF-kappaB pathway. In human, resistin levels are increased in the serum of obese individuals and resistin is used as a severity marker of asthma.

Aufreinigung: Puified

Reinheit: >95 % (SDS-PAGE)

Immunogen: Recombinant human resistin.

Isotyp: IgG2a kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: In PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: After opening, prepare aliquots and store at -20 °C.Avoid freeze/thaw cycles.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung:

+4°C

Stable for at least 1 year after receipt when stored at -20°C.

Details zu Resistin

Target: Resistin (RETN)

Andere Bezeichnung: Resistin

UniProt: Q9HD89

Pathways: Feeding Behaviour, Smooth Muscle Cell Migration