NLRP3 Antikörper (Biotin)

Produktnummer ABIN7566438

Dieser Anti-NLRP3-Antikörper ist ein Maus-Monoklonal-Antikörper zum Nachweis von NLRP3 in WB, IHC, ICC, IP und ChIP. Geeignet für Human und Maus.

Kurzübersicht für NLRP3 Antikörper (Biotin) (ABIN7566438)

Target: NLRP3 (NLR Family, Pyrin Domain Containing 3 (NLRP3))

Reaktivität: Human, Maus

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser NLRP3 Antikörper ist konjugiert mit Biotin

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunoprecipitation (IP), Chromatin Immunoprecipitation (ChIP)

Klon: Cryo-2

Produktdetails anti-NLRP3 Antikörper (Biotin)

Verwendungszweck: anti-NLRP3/NALP3, mAb (Cryo-2) (Biotin)

Produktmerkmale:

Monoclonal Antibody. Recognizes mouse and human NLRP3/NALP3. Applications: IHC, IP, WB. Clone: Cryo-2. Isotype: Mouse IgG2b. Liquid. In PBS containing 0.02 % Proclin300. The inflammasome is a multiprotein complex that mediates the activation of caspase-1, which promotes, amongst others, the secretion of the proinflammatory cytokines interleukin (IL)-1beta and IL-18. Members of the Nod-like receptor family, including NLRP3/NALP3, are critical components of the inflammasome that link danger-signals to caspase-1 activation. Defects in NLRP3 are the cause of familial cold autoinflammatory syndrome type 1 (FCAS1), Muckle-Wells syndrome (MWS) and of chronic infantile neurologic cutaneous and articular syndrome (CINCA).

The inflammasome is a multiprotein complex that mediates the activation of caspase-1, which promotes, amongst others, the secretion of the proinflammatory cytokines interleukin (IL)-1beta and IL-18. Members of the Nod-like receptor family, including NLRP3/NALP3, are critical components of the inflammasome that link danger-signals to caspase-1 activation. Defects in NLRP3 are the cause of familial cold autoinflammatory syndrome type 1 (FCAS1), Muckle-Wells syndrome (MWS) and of chronic infantile neurologic cutaneous and articular syndrome (CINCA).

Aufreinigung: Puified

Reinheit: >95 % (SDS-PAGE)

Immunogen: Recombinant mouse NLRP3/NALP3 (pyrin domain/aa 1-93).

Isotyp: IgG2b

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: In PBS containing 0.02 % Proclin300.

Handhabung: After opening, prepare aliquots and store at -20 °C.Avoid freeze/thaw cycles.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung:

+4°C

Stable for at least 1 year after receipt when stored at -20°C.

Details zu NLRP3

Target: NLRP3 (NLR Family, Pyrin Domain Containing 3 (NLRP3))

Andere Bezeichnung: NLRP3/NALP3

Pathways: Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Endopeptidase Activity, Inflammasome