ACE2 Antikörper (Atto 647N)

Produktnummer ABIN7566404

Der Maus Monoklonal anti-ACE2 Antikörper wird verwendet zum Nachweis von ACE2 in Proben von Human. Er wurde validiert für FACS.

Kurzübersicht für ACE2 Antikörper (Atto 647N) (ABIN7566404)

Target: ACE2 (Angiotensin I Converting Enzyme 2 (ACE2))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser ACE2 Antikörper ist konjugiert mit Atto 647N

Applikation: Flow Cytometry (FACS)

Klon: AC18F

Produktdetails anti-ACE2 Antikörper (Atto 647N)

Verwendungszweck: anti-ACE2 (human), mAb (AC18F) (ATTO 647N)

Spezifität: Recognizes human ACE2. Does not detect recombinant human ACE2 that has a tag at the C-terminus of the protein.

Produktmerkmale: Monoclonal Antibody. Recognizes human ACE2. Application: ELISA, FACS, WB. Clone: AC18F. Isotype: Mouse IgG1κ. Liquid. In PBS. Angiotensin-converting enzyme2 (ACE2) is an ectoenzyme (carboxypeptidase) with an extracellular catalytic domain that predominantly localizes at the plasma membrane and is thereby able to hydrolyze circulating peptides. ACE2 has approximately 42 % sequence identity with ACE, and its cytoplasmic and transmembrane domains show 48 % homology to the protein collectrin that plays a critical role in the amino acid absorption of the kidney. ACE2 converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. ACE2 is involved in the regulation of systemic blood pressure and has direct effects on cardiac functions. It is expressed predominantly in endothelial cells of the lung, gut, heart and kidney. ACE2 together with the protease TMPRSS2 acts as a functional receptor for SARS coronavirus as well as for the new highly pathogenic coronavirus, 2019-nCoV/SARS-CoV-2, which is cause for pneumonia COVID-19.

Immunogen: Recombinant human ACE2.

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: In PBS.

Handhabung: Do not freeze.Protect from light.

Lagerung: 4 °C

Informationen zur Lagerung:

+4°C

+4°C

Keep conjugated formats at +4°C. Stable for at least 1 year after receipt when stored at +4°C.

Haltbarkeit: 12 months

Details zu ACE2

Target: ACE2 (Angiotensin I Converting Enzyme 2 (ACE2))

Andere Bezeichnung: ACE2

Hintergrund:

Alternate Names/Synonyms: SARS Receptor, Angiotensin-converting Enzyme 2, ACEH, Metalloprotease MPROT15, SARS-CoV-2 Receptor

Product Description: Angiotensin-converting enzyme2 (ACE2) is an ectoenzyme (carboxypeptidase) with an extracellular catalytic domain that predominantly localizes at the plasma membrane and is thereby able to hydrolyze circulating peptides. ACE2 has approximately 42 % sequence identity with ACE, and its cytoplasmic and transmembrane domains show 48 % homology to the protein collectrin that plays a critical role in the amino acid absorption of the kidney. ACE2 converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. ACE2 is involved in the regulation of systemic blood pressure and has direct effects on cardiac functions. It is expressed predominantly in endothelial cells of the lung, gut, heart and kidney. ACE2 together with the protease TMPRSS2 acts as a functional receptor for SARS coronavirus as well as for the new highly pathogenic coronavirus, 2019-nCoV/SARS-CoV-2, which is cause for pneumonia COVID-19.

Pathways: ACE Inhibitor Pathway, Peptide Hormone Metabolism, Regulation of Systemic Arterial Blood Pressure by Hormones, Feeding Behaviour