Rekombinanter p40 (p63 Delta) (AA 4-19) Antikörper

Produktnummer ABIN7543298

Produktdetails

Target: p40 (p63 Delta)

Antikörpertyp: Recombinant Antibody

Bindungsspezifität: AA 4-19

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Chimeric

Konjugat: Unkonjugiert

Applikation: Immunohistochemistry (IHC), ELISA

Verwendungszweck: Anti-p40 [14D5E8F12], Rabbit IgG, kappa

Spezifität: This antibody is specific for the p40 peptide of the human p63. P63 protein acts as a sequence specific DNA binding transcriptional activator or repressor. It is also involved in notch signaling by probably inducing JAG1 and JAG2 and plays a role in the regulation of epithelial morphogenesis. The p63 Molecule has a high degree of structural homology with p53 and has three similar functional domains: N-terminal transcription activation region, core DNA binding region, and C-terminal oligomerization region.

Produktmerkmale:

Original Species of Ab: Mouse

Original Format of Ab: IgG1

Aufreinigung: Protein A affinity purified

Immunogen: The original antibody was generated by immunizing mice with p40 peptide comprising amino acids 4-19 (LENNAQTQFSEPQYTN) of the p63 protein (Uniprot -Q9H3D4). The p40 peptide had a sulfhydryl group at its N-terminus and a carrier protein KLH to improve its immunogenicity.

Klon: 14D5E8F12

Isotyp: IgG kappa

Anwendungsinformationen

Applikationshinweise: This antibody is highly similar to commercially available rabbit antibody ZR8 in immunohistochemical staining of p40. This antibody does not stain lung adenocarcinoma but positively stains lung squamous cell carcinoma. This antibody can used for the differential diagnosis of lung squamous cell carcinoma and lung adenocarcinoma via immunohistochemical staining. This binding specificity and affinity of this antibody was determined using ELISA. The original IgG1 antibody is reported to bind human p40 with an affinity constant of 5.99 X 10^9 M^(-1) (CN104447994).

Kommentare:

This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG1 format for improved compatibility with existing reagents assays and techniques.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 mg/mL

Buffer: PBS with 0.02 % Proclin 300.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.

Antigendetails

Target: p40 (p63 Delta)

Andere Bezeichnung: p40

Hintergrund: TP63, CUSP, Tumor protein 63, chronic ulcerative stomatitis protein, Keratinocyte transcription factor KET, Transformation-related protein 63, Tumor protein p73-like, p73L, p40, p51, ZR8

UniProt: Q9H3D4