Rekombinanter CD47 Antikörper (Extracellular Domain)

Produktnummer ABIN7543262

Dieses Kaninchen Chimeric-Antikörper erkennt spezifisch CD47 in FACS und ELISA. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für Rekombinanter CD47 Antikörper (Extracellular Domain) (ABIN7543262)

Target: CD47

Antikörpertyp: Recombinant Antibody

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Chimeric

Konjugat: Dieser CD47 Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS), ELISA

Klon: 2D14

Produktdetails anti-CD47 Antikörper

Bindungsspezifität: Extracellular Domain

Verwendungszweck: Anti-CD47 [2D14], Rabbit IgG, kappa

Spezifität: This antibody binds the extracellular domain of the human CD47, which is broadly distributed on normal adult tissues, as well as ovarian tumors, and is especially abundant in some epithelia and the brain. IAP or integrin assocaited protein has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins. It further plays an important role in memory formation and synaptic plasticity in the hippocampus. It also acts as a receptor for SIRPA. Binding to SIRPA prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells.

Produktmerkmale:

Original Species of Ab: Mouse

Original Format of Ab: IgG1

Aufreinigung: Protein A affinity purified

Immunogen: The original antibody was generated by immunizing BALB/c mice with recombinant human CD47 extracellular domain with equal volume of adjuvant as an immunogen.

Isotyp: IgG kappa

Anwendungsinformationen

Applikationshinweise: The binding specificity of this antibody for recombinant human CD47 was done using ELISA. This antibody is capable of detecting CD47 expressed on the cell surface of K562 (human chronic myeloid leukemia cells) in a flow cytometry (CN110066336).

Kommentare:

This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG1 format for improved compatibility with existing reagents assays and techniques.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 mg/mL

Buffer: PBS with 0.02 % Proclin 300.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.

Details zu CD47

Target: CD47

Andere Bezeichnung: CD47

Hintergrund: IAP, MER6, OV-3, Leukocyte surface antigen CD47, Antigenic surface determinant protein OA3, Integrin-associated protein, Protein MER6, ovarian cancer marker

UniProt: Q08722