Rekombinanter beta Amyloid Antikörper

Produktnummer ABIN7543179

Der Human Chimeric Anti-beta Amyloid-Antikörper wurde für WB, ELISA, IHC und IP validiert. Er ist geeignet, beta Amyloid in Proben von Human zu detektieren.

Kurzübersicht für Rekombinanter beta Amyloid Antikörper (ABIN7543179)

Target: beta Amyloid (Abeta) (Amyloid beta (Abeta))

Antikörpertyp: Recombinant Antibody

Reaktivität: Human

Wirt: Human

Klonalität: Chimeric

Konjugat: Dieser beta Amyloid Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunoprecipitation (IP)

Klon: 21F12

Produktdetails anti-beta Amyloid Antikörper

Verwendungszweck: Anti-Amyloid Beta [21F12], Human IgG1, kappa

Spezifität: This antibody recognizes amino acids 33-42 of amyloid beta.

Produktmerkmale:

Original Species of Ab: Mouse

Original Format of Ab: IgG2b

Aufreinigung: Protein A affinity purified

Immunogen: The original antibody was generated by immunizing A/J mice with a synthetic peptide (NH2-CYS-NH-CH2-(CH2)5-CO-GLMVGGVVIA-COOH) as an immunogen.

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise: This antibody has very high specificity for Aβ1-42 over Aβ1-40. This antibody is capable of immunoprecipitating Aβ peptides ending at aa position 42 and also p3 peptides (PMID: 8917563). This antibody is also recomended for detection of amyloid beta using sandwich ELISA (PMID: 9037091, 19204155). This antibody was also used in the quantification of the proportion of full-length Aβ using western blotting (PMID: 12787077). This antibody has also been used for the identification of Aβ42 plaques on paraffin frontal sections(PMID: 15215183, 19660650). This antibody is unable to bind plaques in unfixed brain sections. This antibody is also not capable of clearing plaque after in vivo administration (PMID: 10932230).

Kommentare:

This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG2b format, for improved compatibility with existing reagents, assays and techniques.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 mg/mL

Buffer: PBS with 0.02 % Proclin 300.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.

Details zu beta Amyloid

Target: beta Amyloid (Abeta) (Amyloid beta (Abeta))

Andere Bezeichnung: Amyloid Beta

Hintergrund: Abeta, A-beta, Aβ, Aβ42, Alzheimer disease amyloid protein, S-APP-beta

UniProt: P05067

Pathways: Inflammasome