Rekombinanter beta Amyloid Antikörper (AA 33-42)

Produktnummer ABIN7543179

Der Human Chimeric anti-beta Amyloid Antikörper wird verwendet zum Nachweis von beta Amyloid in Proben von Human. Er wurde validiert für WB, ELISA, IHC und IP.

Kurzübersicht für Rekombinanter beta Amyloid Antikörper (AA 33-42) (ABIN7543179)

Target: beta Amyloid (Abeta) (Amyloid beta (Abeta))

Antikörpertyp: Recombinant Antibody

Reaktivität: Human

Wirt: Human

Klonalität: Chimeric

Konjugat: Dieser beta Amyloid Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunoprecipitation (IP)

Klon: 21F12

Produktdetails anti-beta Amyloid Antikörper

Bindungsspezifität: AA 33-42

Verwendungszweck: Anti-Amyloid Beta [21F12], Human IgG1, kappa

Spezifität:

This antibody recognizes amino acids 33-42 of amyloid beta.

Application Notes original Clone: This antibody has very high specificity for Aβ1-42 over Aβ1-40. This antibody is capable of immunoprecipitating Aβ peptides ending at aa position 42 and also p3 peptides (PMID: 8917563). This antibody is also recomended for detection of amyloid beta using sandwich ELISA (PMID: 9037091, 19204155). This antibody was also used in the quantification of the proportion of full-length Aβ using western blotting (PMID: 12787077). This antibody has also been used for the identification of Aβ42 plaques on paraffin frontal sections(PMID: 15215183, 19660650). This antibody is unable to bind plaques in unfixed brain sections. This antibody is also not capable of clearing plaque after in vivo administration (PMID: 10932230).

Produktmerkmale: This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG2b format, for improved compatibility with existing reagents, assays and techniques.

Aufreinigung: Protein A affinity purified

Immunogen: The original antibody was generated by immunizing A/J mice with a synthetic peptide (NH2-CYS-NH-CH2-(CH2)5-CO-GLMVGGVVIA-COOH) as an immunogen.

Isotyp: IgG1, kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

OriginalSpeciesName: Mouse

OriginalFormat: IgG2b

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 mg/mL

Buffer: PBS with 0.02 % Proclin 300.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.

Details zu beta Amyloid

Target: beta Amyloid (Abeta) (Amyloid beta (Abeta))

Andere Bezeichnung: Amyloid Beta

Hintergrund: Abeta, A-beta, Aβ, Aβ42, Alzheimer disease amyloid protein, S-APP-beta

UniProt: P05067

Pathways: Inflammasome