Rekombinanter ICOS Antikörper
Kurzübersicht für Rekombinanter ICOS Antikörper (ABIN7543074)
Target
Alle ICOS Antikörper anzeigenAntikörpertyp
Reaktivität
Wirt
Klonalität
Konjugat
Applikation
Klon
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Verwendungszweck
- Anti-ICOS [7E.17G9], Rabbit IgG, kappa
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Spezifität
- This anitbody binds to mouse ICOS (CD278).
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Produktmerkmale
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Original Species of Ab: Rat
Original Format of Ab: IgG2b
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Aufreinigung
- Protein A affinity purified
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Immunogen
- Rats were immunized i.m. three times with 500 mg murine ICOS cDNA in the pAXEF mammalian expression vector and boosted twice with 200 mg murine ICOS hexahistidine fusion protein.
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Isotyp
- IgG kappa
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Applikationshinweise
- This antibody can be used to detect mouse ICOS by flow-cytometry. Maazi et al (2015, PMID: 25769613) showed that 7E.17G9 can inhibit ICOS interaction with its ligand ICOSL.
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Kommentare
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This chimeric rabbit antibody was made using the variable domain sequences of the original Rat IgG2b format, for improved compatibility with existing reagents, assays and techniques.
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Konzentration
- 1 mg/mL
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Buffer
- PBS with 0.02 % Proclin 300.
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Konservierungsmittel
- ProClin
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Vorsichtsmaßnahmen
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Lagerung
- 4 °C,-20 °C
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Informationen zur Lagerung
- Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
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- ICOS (Inducible T-Cell Co-Stimulator (ICOS))
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Andere Bezeichnung
- ICOS
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Hintergrund
- CD278, AILIM, CVID1, inducible T-cell co-stimulator, inducible T-cell costimulator, 7E.17G9.G1.G7
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Pathways
- Cancer Immune Checkpoints
Target
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