GRIN1/NMDAR1 Antikörper

Produktnummer ABIN7540588

Hersteller Produkt- Nr.: 600-401-d88

Dieses Anti-GRIN1/NMDAR1-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von GRIN1/NMDAR1 in WB und IHC. Geeignet für Ratte.

Kurzübersicht für GRIN1/NMDAR1 Antikörper (ABIN7540588)

Target: GRIN1/NMDAR1 (GRIN1) (Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 1 (GRIN1))

Reaktivität: Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GRIN1/NMDAR1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-GRIN1/NMDAR1 Antikörper

Hersteller Produkt- Nr.: 600-401-d88

Hersteller: Rockland

Verwendungszweck: NMDA R1, Splice Variant N1 Antibody

Kreuzreaktivität (Details): Anti-NMDA R1, Splice Variant N1 antibody is directed against NMDA R1 protein.

Aufreinigung: The antibody was affinity purified from monospecific antiserum by immunoaffinity purification.

Immunogen: Anti-NMDA NR1 Subunit, Splice Variant N1 Antibody was produced by repeated immunizations with a synthetic peptide corresponding to amino acid residues specific to the NR1 subunit, N1 splice variant insert.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

Immunohistochemistry_Dilution: 1:1000

Western_Blot_Dilution: 1:1000

Other: User Optimized

Kommentare:

Anti-NMDA R1, Splice Variant N1 (Rabbit) Antibody is tested for use in Western Blotting and IHC. Specific conditions for reactivity should be optimized by the end user. Expect a band of approximately 120 kDa in size corresponding to the NR1 subunit, NR1 splice variant insert protein of the NMDA receptor in the appropriate cell lysate or extract.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution:

Reconstitution_Buffer: Neutral PBS

Reconstitution_Volume: 50μL

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store vial at 4° C prior to restoration.   For extended storage aliquot contents and freeze at -20° C or below.  Avoid cycles of freezing and thawing.  Centrifuge product if not completely clear after standing at room temperature.  Dilute only prior to immediate use. 

Haltbarkeit: 12 months

Details zu GRIN1/NMDAR1

Target: GRIN1/NMDAR1 (GRIN1) (Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 1 (GRIN1))

Andere Bezeichnung: Grin1

Hintergrund: Glutamate [NMDA] receptor subunit zeta-1,N-methyl-D-aspartate receptor subunit NR1, NMD-R1, Grin1,NMDA R1, Splice Variant N1 Antibody detects NMDA R1 protein. The ion channels activated by glutamate that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA Receptors (NMDAR). The NMDAR plays an essential role in memory, neuronal development and it has also been implicated in several disorders of the central nervous system including Alzheimer's, epilepsy and ischemic neuronal cell death. There are a number of different splice variants of the NR1-Subunit. Differential splicing of three exons in the NR1-Subunit generates up to eight NR1-Subunit splice variants and 7 of these have been identified in cDNA libraries. These exons encode a 21 amino acid N-terminal domain (N1) and adjacent sequences in the C-terminus (C1 and C2). Splicing out the C2 cassette eliminates the first stop codon and produces a new reading frame that generates a new sequence of 22 amino acids (C2'). Considerable attention has been focused on the distribution and expression of these splice variants that may affect the functional properties and regulation of the NMDAR. Anti-NMDA R1, Splice Variant N1 Antibody is ideal for investigators involved in Neuroscience and Signal Transduction research.

Gen-ID: 24408

NCBI Accession: NP_058706

UniProt: P35439

Pathways: Synaptic Membrane, Feeding Behaviour, Regulation of long-term Neuronal Synaptic Plasticity