C9ORF72 Antikörper (AA 110-199)

Produktnummer ABIN7539797

Dieses Anti-C9ORF72-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von C9ORF72 in WB, ELISA, IHC, FACS und ICC. Geeignet für Human, Ratte, Maus und Affe.

Kurzübersicht für C9ORF72 Antikörper (AA 110-199) (ABIN7539797)

Target: C9ORF72 (Chromosome 9 Open Reading Frame 72 (C9ORF72))

Reaktivität: Human, Ratte, Maus, Affe

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser C9ORF72 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunocytochemistry (ICC)

Klon: 6D6F12

Produktdetails anti-C9ORF72 Antikörper

Bindungsspezifität: AA 110-199

Verwendungszweck: C9orf72 Antibody

Aufreinigung: Purified antibody

Immunogen: Purified recombinant fragment of human C9orf72 (AA: 110-199) expressed in E. Coli.

Isotyp: IgG2b

Anwendungsinformationen

Applikationshinweise:

ELISA: 1/10000

FCM: 1/200 - 1/400

ICC: 1/200 - 1/1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Details zu C9ORF72

Target: C9ORF72 (Chromosome 9 Open Reading Frame 72 (C9ORF72))

Andere Bezeichnung: C9orf72

Hintergrund: The protein encoded by this gene plays an important role in the regulation of endosomal trafficking, and has been shown to interact with Rab proteins that are involved in autophagy and endocytic transport. Expansion of a GGGGCC repeat from 2-22 copies to 700-1600 copies in the intronic sequence between alternate 5' exons in transcripts from this gene is associated with 9p-linked ALS (amyotrophic lateral sclerosis) and FTD (frontotemporal dementia) (PMID: 21944778, 21944779). Studies suggest that hexanucleotide expansions could result in the selective stabilization of repeat-containing pre-mRNA, and the accumulation of insoluble dipeptide repeat protein aggregates that could be pathogenic in FTD-ALS patients (PMID: 23393093). Alternative splicing results in multiple transcript variants encoding different isoforms.

Molekulargewicht: 54.3 kDa