MCM3 Antikörper

Produktnummer ABIN7539779

Dieses Anti-MCM3-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von MCM3 in WB, IHC, ICC und FACS. Geeignet für Human, Ratte und Affe.

Kurzübersicht für MCM3 Antikörper (ABIN7539779)

Target: MCM3 (Minichromosome Maintenance Complex Component 3 (MCM3))

Reaktivität: Human, Ratte, Affe

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser MCM3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Flow Cytometry (FACS)

Klon: 1D4A3

Produktdetails anti-MCM3 Antikörper

Verwendungszweck: MCM3 Antibody

Aufreinigung: Purified antibody

Immunogen: Purified recombinant fragment of human MCM3 expressed in E. Coli.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise:

FCM: 1/200 - 1/400

ICC: 1/50 - 1/200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Details zu MCM3

Target: MCM3 (Minichromosome Maintenance Complex Component 3 (MCM3))

Andere Bezeichnung: MCM3

Hintergrund: The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein is a subunit of the protein complex that consists of MCM2-7. It has been shown to interact directly with MCM5/CDC46. This protein also interacts with and is acetylated by MCM3AP, a chromatin-associated acetyltransferase. The acetylation of this protein inhibits the initiation of DNA replication and cell cycle progression. Several transcript variants encoding different isoforms have been found for this gene.

Molekulargewicht: 91 kDa

Gen-ID: 4172

UniProt: P25205

Pathways: DNA Reparatur, Mitotic G1-G1/S Phases, DNA Replication, Chromatin Binding, Synthesis of DNA