SCIMP Antikörper (PE)

Produktnummer ABIN7506008

Dieser Anti-SCIMP-Antikörper ist ein Maus-Monoklonal-Antikörper zum Nachweis von SCIMP in ICFC. Geeignet für Human.

Kurzübersicht für SCIMP Antikörper (PE) (ABIN7506008)

Target: SCIMP (SLP Adaptor and CSK Interacting Membrane Protein (SCIMP))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser SCIMP Antikörper ist konjugiert mit PE

Applikation: Intracellular Flow Cytometry (ICFC)

Klon: NVL-07

Produktdetails anti-SCIMP Antikörper (PE)

Verwendungszweck: Anti-SCIMP PE

Spezifität: The mouse monoclonal antibody NVL-07 recognizes intracellular part of human transmembrane adaptor SCIMP. This protein of 17 kDa predicted Mw migrates as a 22 kDa band on SDS PAGE.

Aufreinigung: Purified antibody is conjugated with R-phycoerythrin (PE) under optimum conditions. Unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.

Immunogen: Recombinant intracellular part of human SCIMP

Isotyp: IgG2a

Anwendungsinformationen

Applikationshinweise: Flow cytometry: The reagent is designed for analysis of human blood cells using 10 μL reagent / 100 μL of whole blood or 10⁶ cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests. Intracellular staining.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

Details zu SCIMP

Target: SCIMP (SLP Adaptor and CSK Interacting Membrane Protein (SCIMP))

Andere Bezeichnung: SCIMP

Hintergrund: SLP adaptor and CSK interacting membrane protein,SCIMP (SLP adaptor and Csk interacting membrane protein), also known as Nvl, is a palmitoylated transmembrane adaptor protein expressed in professional antigen presenting cells, most prominently in the lymph nodes and spleen. It is associated with tetraspanin-enriched microdomains (together with MHC II). There is a close relationship between SCIMP and tyrosinkinase Lyn, which is constitutively bound to it by its SH3 domain. After MHC II-mediated stimulation in the immunological synapse SCIMP becomes phosphorylated at several tyrosine residues and provides docking sites for Grb2 and SLP65 or SLP76 adaptors transducing the signal downstream, as well as for the kinase Csk with modulatory roles.,NVL

Gen-ID: 388325

UniProt: Q6UWF3