LIFR Antikörper (PE)

Produktnummer ABIN7505851

Der Maus Monoklonal Anti-LIFR-Antikörper wurde für FACS validiert. Er ist geeignet, LIFR in Proben von Human zu detektieren.

Kurzübersicht für LIFR Antikörper (PE) (ABIN7505851)

Target: LIFR (Leukemia Inhibitory Factor Receptor alpha (LIFR))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser LIFR Antikörper ist konjugiert mit PE

Applikation: Flow Cytometry (FACS)

Klon: 12D3

Produktdetails anti-LIFR Antikörper (PE)

Verwendungszweck: Anti-Hu CD118 PE

Spezifität: The mouse monoclonal antibody 12D3 recognizes an extracellular epitope of CD118, a transmembrane glycoprotein, which associates with CD130 to form the functional high affinity LIF receptor.

Aufreinigung: Purified antibody is conjugated with R-phycoerythrin (PE) under optimum conditions. Unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.

Immunogen: human recombinant soluble CD118-Fc

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise: Flow cytometry: Recommended dilution: 4-10 μg/mL.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.1 mg/mL

Buffer: Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

Details zu LIFR

Target: LIFR (Leukemia Inhibitory Factor Receptor alpha (LIFR))

Andere Bezeichnung: CD118

Hintergrund: LIF receptor subunit alpha,CD118 (LIFR alpha) is a type I transmembrane glycoprotein of the cytokine receptor family, which associates noncovalently with CD130 to form the functional high affinity LIF receptor, which also acts as an oncostatin M receptor. CD118 alone binds LIF with low affinity. A secreted form of CD118 results from alternative splicing, and may have inhibitory effect, as it also binds LIF, although with low affinity. CD118 is not expressed on lymphocytes, but it is widely expressed outside the immune system. Soluble CD118 level rises during pregnancy, in parallel with a drop in circulating LIF levels.,LIFR alpha, SWS, SJS2, STWSm, gp190

Gen-ID: 3977

UniProt: P42702

Pathways: JAK-STAT Signalweg, Growth Factor Binding