Rekombinanter CEA Antikörper

Produktnummer ABIN7487714

Dieses Kaninchen Chimeric-Antikörper erkennt spezifisch CEA in ISG. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für Rekombinanter CEA Antikörper (ABIN7487714)

Target: CEA (Carcinoembryonic Antigen Gene Family (CEA))

Antikörpertyp: Recombinant Antibody

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Chimeric

Konjugat: Dieser CEA Antikörper ist unkonjugiert

Applikation: Immunoscintigraphy (ISG)

Klon: BW431-26

Produktdetails anti-CEA Antikörper

Verwendungszweck: Anti-CEA [BW431/26], Rabbit IgG, kappa

Spezifität: This antibody recognizes and binds human carcinoembryonic antigen in its purified state as well as on tissue sections.

Produktmerkmale:

Original Species of Ab: Mouse

Original Format of Ab: IgG3

Aufreinigung: Protein A affinity purified

Immunogen: The original antibody was generated by immunizing mice with CEA positive adenocarcinoma cells preferably from lungs.

Isotyp: IgG kappa

Anwendungsinformationen

Applikationshinweise: Technetium 99-labeled (Tc-99m) BW431/26 has been used in the diagnosis and detection of colorectal carcinomas, breast cancers, bladder carcinomas, lung adenocarcinomas and their recurrences by immunoscintigraphy (PMID: 2602902, 2662074, 2685692, 2297747, 2157833, 2166552, 2383485, 1984945 ). The use of Tc-99m-BW 431/26 immunoconjugates in immunoscintigraphy resulted in reduction of radiation dose for the patient down to 5 % of the dose applied as compared with I-131 labelled MAbs (PMID: 3262953). Humanized version of this antibody also shows similar binding affinity as compared to its murine parent antibody (PMID: 1762576).

Kommentare:

This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG3 format, for improved compatibility with existing reagents, assays and techniques.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 mg/mL

Buffer: PBS with 0.02 % Proclin 300.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.

Details zu CEA

Target: CEA (Carcinoembryonic Antigen Gene Family (CEA))

Andere Bezeichnung: CEA

Hintergrund: Carcinoembryonic antigen, Carcinoembryonic antigen-related cell adhesion molecule 5, CEACAM5, Meconium antigen 100, CD66e

UniProt: P06731