MBTPS1 Antikörper

Produktnummer ABIN7467779

Der Kaninchen Polyklonal anti-MBTPS1 Antikörper (ABIN7467779) detektiert spezifisch MBTPS1 in WB. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für MBTPS1 Antikörper (ABIN7467779)

Target: MBTPS1 (Membrane-Bound Transcription Factor Peptidase, Site 1 (MBTPS1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MBTPS1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-MBTPS1 Antikörper

Kreuzreaktivität: Human

Aufreinigung: Purified by antigen-affinity chromatography.

Immunogen: Recombinant protein encompassing a sequence within the center region of human MBTPS1. The exact sequence is proprietary.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.89 mg/mL

Buffer: 1XPBS ( pH 7), 1 % BSA, 20 % Glycerol, 0.01 % Thimerosal

Konservierungsmittel: Thimerosal (Merthiolate)

Vorsichtsmaßnahmen: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Details zu MBTPS1

Target: MBTPS1 (Membrane-Bound Transcription Factor Peptidase, Site 1 (MBTPS1))

Andere Bezeichnung: membrane bound transcription factor peptidase, site 1

Hintergrund: Membrane bound transcription factor peptidase, site 1 , PCSK8 , S1P , SKI-1,The encoded protein has a central role in the regulation of lipid metabolism in cells. It is a sterol-regulated subtilisin-like serine protease that cleaves ER membrane-bound sterol regulatory element-binding proteins (SREBPs), a reaction that initiates the two-step proteolytic process by which transcriptionally active fragments of SREBPs are released from the membrane for translocation to the nucleus. The gene product is an integral membrane ER protein, with the bulk located in the ER lumen. It is synthesized as an inactive preproprotein that is self-activated by an intramolecular cleavage that generates the mature protein. [provided by RefSeq]

Molekulargewicht: 118 kDa

Gen-ID: 8720

UniProt: Q14703

Pathways: ER-Nucleus Signaling