MBTPS1 Antikörper (C-Term)

Produktnummer ABIN7180200

Produktdetails anti-MBTPS1 Antikörper

Target: MBTPS1 (Membrane-Bound Transcription Factor Peptidase, Site 1 (MBTPS1))

Bindungsspezifität: C-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MBTPS1 Antikörper ist unkonjugiert

Applikation: ELISA, Western Blotting (WB)

Kreuzreaktivität: Human, Maus, Ratte

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from C-terminal of Human MBTPS1.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB:1:500-1:3000,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu MBTPS1

Target: MBTPS1 (Membrane-Bound Transcription Factor Peptidase, Site 1 (MBTPS1))

Andere Bezeichnung: MBTPS1 (MBTPS1 Produkte)

Synonyme: PCSK8 antikoerper, S1P antikoerper, SKI-1 antikoerper, 0610038M03Rik antikoerper, AV003995 antikoerper, Ski1 antikoerper, mKIAA0091 antikoerper, S1p antikoerper, Ski-1 antikoerper, membrane bound transcription factor peptidase, site 1 antikoerper, membrane-bound transcription factor peptidase, site 1 antikoerper, MBTPS1 antikoerper, Mbtps1 antikoerper

Hintergrund:

Background: Serine protease that catalyzes the first step in the proteolytic activation of the sterol regulatory element-binding proteins (SREBPs). Other known substrates are BDNF, GNPTAB and ATF6. Cleaves after hydrophobic or small residues, provided that Arg or Lys is in position P4. Cleaves known substrates after Arg-Ser-Val-Leu (SERBP-2), Arg-His-Leu-Leu (ATF6), Arg-Gly-Leu-Thr (BDNF) and its own propeptide after Arg-Arg-Leu-Leu. Mediates the protein cleavage of GNPTAB into subunit alpha and beta, thereby participating in biogenesis of lysosomes.

Nakajima T., J. Hum. Genet. 45:212-217(2000).
Nagase T., DNA Res. 2:37-43(1995).
Bechtel S., BMC Genomics 8:399-399(2007).

Aliases: MBTPS1 antibody, KIAA0091 antibody, S1P antibody, SKI1Membrane-bound transcription factor site-1 protease antibody, EC 3.4.21.112 antibody, Endopeptidase S1P antibody, Subtilisin/kexin-isozyme 1 antibody, SKI-1 antibody

UniProt: Q14703

Pathways: ER-Nucleus Signaling