Telefon:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@antikoerper-online.de

DDR1 Antikörper (C-Term)

Dieses Anti-DDR1-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von DDR1 in WB und IHC (p). Geeignet für Human.
Produktnummer ABIN7467431

Kurzübersicht für DDR1 Antikörper (C-Term) (ABIN7467431)

Target

Alle DDR1 Antikörper anzeigen
DDR1 (Discoidin Domain Receptor tyrosine Kinase 1 (DDR1))

Reaktivität

  • 89
  • 36
  • 35
  • 4
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
Human

Wirt

  • 90
  • 13
  • 3
Kaninchen

Klonalität

  • 88
  • 15
  • 2
Polyklonal

Konjugat

  • 54
  • 6
  • 4
  • 3
  • 3
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
Dieser DDR1 Antikörper ist unkonjugiert

Applikation

  • 78
  • 41
  • 26
  • 26
  • 23
  • 16
  • 12
  • 7
  • 6
  • 6
  • 6
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
  • Bindungsspezifität

    • 25
    • 15
    • 7
    • 7
    • 7
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term

    Kreuzreaktivität

    Human

    Aufreinigung

    Purified by antigen-affinity chromatography.

    Immunogen

    Recombinant protein encompassing a sequence within the C-terminus region of human DDR1. The exact sequence is proprietary.

    Isotyp

    IgG
  • Applikationshinweise

    WB: 1:500-1:3000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

    Kommentare

    Positive Control: THP-1

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    1.03 mg/mL

    Buffer

    0.1M Tris-Glycine ( pH 7), 20 % Glycerol, 0.01 % Thimerosal

    Konservierungsmittel

    Thimerosal (Merthiolate)

    Vorsichtsmaßnahmen

    This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
  • Target

    DDR1 (Discoidin Domain Receptor tyrosine Kinase 1 (DDR1))

    Andere Bezeichnung

    discoidin domain receptor tyrosine kinase 1

    Hintergrund

    Discoidin domain receptor tyrosine kinase 1 , CAK , CD167 , DDR , EDDR1 , HGK2 , MCK10 , NEP , NTRK4 , PTK3 , PTK3A , RTK6 , TRKE,Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene is a RTK that is widely expressed in normal and transformed epithelial cells and is activated by various types of collagen. This protein belongs to a subfamily of tyrosine kinase receptors with a homology region to the Dictyostelium discoideum protein discoidin I in their extracellular domain. Its autophosphorylation is achieved by all collagens so far tested (type I to type VI). In situ studies and Northern-blot analysis showed that expression of this encoded protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, this protein is significantly over-expressed in several human tumors from breast, ovarian, esophageal, and pediatric brain. This gene is located on chromosome 6p21.3 in proximity to several HLA class I genes. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq]

    Molekulargewicht

    101 kDa

    Gen-ID

    780

    UniProt

    Q08345

    Pathways

    RTK Signalweg, Smooth Muscle Cell Migration
Sie sind hier:
Chat with us!