DDB1 Antikörper

Produktnummer ABIN7467425

Dieses Anti-DDB1-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von DDB1 in WB. Geeignet für Human.

Kurzübersicht für DDB1 Antikörper (ABIN7467425)

Target: DDB1 (Damage Specific DNA Binding Protein 1 (DDB1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DDB1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-DDB1 Antikörper

Kreuzreaktivität: Human, Maus, Ratte

Aufreinigung: Affinity purified with antigen

Immunogen: Synthetic peptide conugated to protein carrier.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: For WB: Use at an assay dependent dilution. Predicted molecular weight: 127 kDa. Optimal dilutions/concentrations should be determined by the researcher.

Kommentare:

Positive Control: T47D and MCF-7 whole cell lysate

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: PBS pH 7.2, No Preservative

Konservierungsmittel: Without preservative

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Details zu DDB1

Target: DDB1 (Damage Specific DNA Binding Protein 1 (DDB1))

Andere Bezeichnung: damage specific DNA binding protein 1

Hintergrund: Damage specific DNA binding protein 1 , DDBA , UV-DDB1 , XAP1 , XPCE , XPE , XPE-BF,The protein encoded by this gene is the large subunit (p127) of the heterodimeric DNA damage-binding (DDB) complex while another protein (p48) forms the small subunit. This protein complex functions in nucleotide-excision repair and binds to DNA following UV damage. Defective activity of this complex causes the repair defect in patients with xeroderma pigmentosum complementation group E (XPE) - an autosomal recessive disorder characterized by photosensitivity and early onset of carcinomas. However, it remains for mutation analysis to demonstrate whether the defect in XPE patients is in this gene or the gene encoding the small subunit. In addition, Best vitelliform mascular dystrophy is mapped to the same region as this gene on 11q, but no sequence alternations of this gene are demonstrated in Best disease patients. The protein encoded by this gene also functions as an adaptor molecule for the cullin 4 (CUL4) ubiquitin E3 ligase complex by facilitating the binding of substrates to this complex and the ubiquitination of proteins. [provided by RefSeq, May 2012]

Molekulargewicht: 127 kDa

Gen-ID: 1642

UniProt: Q16531

Pathways: DNA Reparatur