RFWD3 Antikörper (C-Term)

Produktnummer ABIN7466618

Dieses Anti-RFWD3-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von RFWD3 in WB. Geeignet für Human.

Kurzübersicht für RFWD3 Antikörper (C-Term) (ABIN7466618)

Target: RFWD3 (Ring Finger and WD Repeat Domain 3 (RFWD3))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RFWD3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-RFWD3 Antikörper

Bindungsspezifität: C-Term

Kreuzreaktivität: Human

Aufreinigung: Purified by antigen-affinity chromatography.

Immunogen: Recombinant protein encompassing a sequence within the C-terminus region of human RFWD3. The exact sequence is proprietary.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:500-1:3000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Kommentare:

Positive Control: MCF-7

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.96 mg/mL

Buffer: 0.1M Tris-Glycine ( pH 7), 20 % Glycerol, 0.01 % Thimerosal

Konservierungsmittel: Thimerosal (Merthiolate)

Vorsichtsmaßnahmen: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Details zu RFWD3

Target: RFWD3 (Ring Finger and WD Repeat Domain 3 (RFWD3))

Andere Bezeichnung: ring finger and WD repeat domain 3

Hintergrund: Ring finger and WD repeat domain 3 , FANCW , RNF201,E3 ubiquitin-protein ligase that mediates the ubiquitination of p53/TP53 in the late response to DNA damage, and acts as a positive regulator of p53/TP53 stability, thereby regulating the G1/S DNA damage checkpoint. May act by catalyzing the formation of short polyubiquitin chains on p53/TP53 that are not targeted to the proteasome. In response to ionizing radiation, interacts with MDM2 and enhances p53/TP53 ubiquitination, possibly by restricting MDM2 from extending polyubiquitin chains on ubiquitinated p53/TP53.

Molekulargewicht: 85 kDa

Gen-ID: 55159

UniProt: Q6PCD5