BCL2L1 Antikörper (C-Term)

Produktnummer ABIN7464353

Dieses Anti-BCL2L1-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von BCL2L1 in WB, IP und IHC (p). Geeignet für Human.

Kurzübersicht für BCL2L1 Antikörper (C-Term) (ABIN7464353)

Target: BCL2L1 (BCL2-Like 1 (BCL2L1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser BCL2L1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-BCL2L1 Antikörper

Bindungsspezifität: C-Term

Spezifität: GTX124266 Bcl-XS antibody was designed specific for BCL-XS,IP/MS validation was supported by references (PMID:30377416)

Kreuzreaktivität: Human, Ratte

Aufreinigung: Purified by antigen-affinity chromatography.

Immunogen: Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human Bcl-XS. The exact sequence is proprietary.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:500-1:3000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Kommentare:

Positive Control: A549 , H1299 , HCT116 , MCF-7 , PC-12 , Rat2

Validation: IP/MS

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: 0.1M Tris-Glycine ( pH 7), 20 % Glycerol, 0.01 % Thimerosal

Konservierungsmittel: Thimerosal (Merthiolate)

Vorsichtsmaßnahmen: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Details zu BCL2L1

Target: BCL2L1 (BCL2-Like 1 (BCL2L1))

Andere Bezeichnung: BCL2 like 1

Hintergrund: BCL2 like 1 , BCL-XL/S , BCL2L , BCLX , Bcl-X , PPP1R52,The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Two alternatively spliced transcript variants, which encode distinct isoforms, have been reported. The longer isoform acts as an apoptotic inhibitor and the shorter form acts as an apoptotic activator. [provided by RefSeq]

Molekulargewicht: 18.9 kDa

Gen-ID: 598

UniProt: Q07817

Pathways: Apoptose, Negative Regulation of intrinsic apoptotic Signaling