Rekombinanter ThPok (AA 250-300) Antikörper

Produktnummer ABIN7455169

Der Kaninchen Monoklonal anti-ThPok Antikörper wird verwendet zum Nachweis von ThPok in Proben von Human und Maus. Er wurde validiert für IP, WB, FACS, ICC und IHC.

Kurzübersicht für Rekombinanter ThPok (AA 250-300) Antikörper (ABIN7455169)

Target: ThPok

Antikörpertyp: Recombinant Antibody

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Unkonjugiert

Applikation: Immunoprecipitation (IP), Western Blotting (WB), Flow Cytometry (FACS), Immunocytochemistry (ICC), Immunohistochemistry (IHC)

Klon: BLR191J

Produktdetails

Bindungsspezifität: AA 250-300

Verwendungszweck: Rabbit anti-ThPOK Recombinant Monoclonal Antibody [BLR191J]

Aufreinigung: Purified

Immunogen: between AA 250 and 300

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

IHC: 1:100 to 1:500. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

IP: 20 μL/1 mg lysate

ICC: 1:100 to 1:500. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE cell sections.

WB: 01:01,00

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 250 μg/mL

Buffer: Borate Buffered Saline (BBS) pH 8.2 with 0.1 % BSA and 0.09 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: 2 - 8 °C

Haltbarkeit: 12 months

Antigendetails

Target: ThPok

Hintergrund: ZBTB7B is a transcription factor that acts as a key regulator of lineage commitment of immature T-cell precursors. ZBTB7B is necessary and sufficient for commitment of CD4 lineage, while its absence causes CD8 commitment. Development of immature T-cell precursors (thymocytes) to either the CD4 helper or CD8 killer T-cell lineages correlates precisely with their T-cell receptor specificity for major histocompatibility complex class II or class I molecules, respectively. ZBTB7B is also a transcriptional repressor of the collagen COL1A1 and COL1A2 genes and may also function as a repressor of fibronectin and possibly other extracellular matrix genes [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ O15156].

Gen-ID: 51043

UniProt: O15156