AKAP8L Antikörper (AA 596-646)

Produktnummer ABIN7454742

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch AKAP8L in WB, IP und IHC (fp). Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für AKAP8L Antikörper (AA 596-646) (ABIN7454742)

Target: AKAP8L (A Kinase (PRKA) Anchor Protein 8-Like (AKAP8L))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser AKAP8L Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Produktdetails anti-AKAP8L Antikörper

Bindungsspezifität: AA 596-646

Verwendungszweck: Rabbit anti-AKAP8L/HA95 Antibody, Affinity Purified

Aufreinigung: Affinity Purified

Immunogen: between AA 596 and 646

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

IHC: 1:500 - 1:2,000. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

IP: 2 - 5 μg/mg lysate

WB: 1:2,000 - 1:10,000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 200 μg/mL

Buffer: Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Haltbarkeit: 12 months

Details zu AKAP8L

Target: AKAP8L (A Kinase (PRKA) Anchor Protein 8-Like (AKAP8L))

Andere Bezeichnung: AKAP8L/HA95

Hintergrund: Background: AKAP8L/HA95 is a PKA anchoring protein that is localized to the nuclear envelope and associates with chromatin upon nuclear envelope breakdown during mitosis. AKAP8L/HA95 has been found to play an important role in the initiation of DNA replication and may function as a scaffold for proteins such as MCM2 and LAP2beta. Additionally, AKAP8L/HA95 has been shown to co-locate with the PKA C subunit in splicing factor compartments and is involved in the regulation of pre-mRNA splicing. Further support for a scaffolding and splicing role in the nucleus comes from the observation that AKAP8L/HA95 colocalizes with HypA, a splicing-like factor, and through this association may function as a docking site for the nuclear accumulation of Huntington protein as seen in Huntington's disease.

Gen-ID: 26993

NCBI Accession: NP_055186

UniProt: Q9ULX6

Pathways: SARS-CoV-2 Protein Interaktom