General Transcription Factor 3C Polypeptide 3 (GTF3C3) (AA 475-525) Antikörper

Produktnummer ABIN7454731

Der Kaninchen Polyklonal anti-General Transcription Factor 3C Polypeptide 3 Antikörper wird verwendet zum Nachweis von General Transcription Factor 3C Polypeptide 3 in Proben von Human. Er wurde validiert für IP, IHC (fp) und WB.

Kurzübersicht für General Transcription Factor 3C Polypeptide 3 (GTF3C3) (AA 475-525) Antikörper (ABIN7454731)

Target: General Transcription Factor 3C Polypeptide 3 (GTF3C3)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Unkonjugiert

Applikation: Immunoprecipitation (IP), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp)), Western Blotting (WB)

Produktdetails

Bindungsspezifität: AA 475-525

Verwendungszweck: Rabbit anti-GTF3C3/TFIIIC102 Antibody, Affinity Purified

Aufreinigung: Affinity Purified

Immunogen: between AA 475 and 525

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

IHC: 1:200 - 1:1,000. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

IP: 2 - 5 μg/mg lysate

WB: 1:2,000 - 1:10,000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 200 μg/mL

Buffer: Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Haltbarkeit: 12 months

Antigendetails

Target: General Transcription Factor 3C Polypeptide 3 (GTF3C3)

Andere Bezeichnung: GTF3C3/TFIIIC102

Hintergrund: Background: General transcription factor 3C polypeptide 3 (GTF3C3/TFIIIC102) is a subunit of the TFIIIC DNA-binding factor required for transcription of tRNA and 5S rRNA genes by RNA polymerase III. Human TFIIIC is composed of six subunits: TFIIIC220, TFIIIC110, TFIIIC102, TFIIIC90 and TFIIIC63, and TFIIIC35. GTF3C3/TFIIIC102 appears to be important for stable complex formation and recruitment of RNA polymerase III by interacting with TFIIIB90, TBP, and TFIIIC63. GTF3C3/TFIIIC102 has been shown to also interact with DEDD and FLAME-3 proteins. This interaction may function to translocate GTF3C3/TFIIIC102 to the nucleus and regulate TFIIIC activity.

Gen-ID: 9330

NCBI Accession: NP_036218

UniProt: Q9Y5Q9