MAML2 Antikörper (C-Term)

Produktnummer ABIN7454661

Produktdetails anti-MAML2 Antikörper

Target: MAML2 (Mastermind-Like 2 (MAML2))

Bindungsspezifität: C-Term

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MAML2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Verwendungszweck: Rabbit anti-MAML2 Antibody, Affinity Purified

Homologie: Bovine

Aufreinigung: Affinity Purified

Immunogen: between AA 1100 and C-term

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

IHC: 1:200 - 1:1,000. Epitope retrieval with Tris-EDTA pH 9.0 is recommended for FFPE tissue sections.

IP: 1 - 4 μg/mg lysate

WB: 1:2,000 - 1:15,000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 200 μg/mL

Buffer: Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Haltbarkeit: 12 months

Details zu MAML2

Target: MAML2 (Mastermind-Like 2 (MAML2))

Andere Bezeichnung: MAML2 (MAML2 Produkte)

Synonyme: 5930431H10 antikoerper, BC032967 antikoerper, MAM-3 antikoerper, MAM2 antikoerper, MAM3 antikoerper, MLL-MAML2 antikoerper, mastermind like 2 (Drosophila) antikoerper, mastermind-like transcriptional coactivator 2 antikoerper, mastermind like transcriptional coactivator 2 antikoerper, Maml2 antikoerper, MAML2 antikoerper

Hintergrund: Background: There are 3 MAML (mastermind-like) proteins in mammals (MAML1-3). MAML2 is a critical coactivator for NOTCH signaling. MAML2 associates with NOTCH and CSL in a ternary complex and functions to activate transcription of HES and hairy-related basic helix-loop-helix transcription factors. MAML2 has been identified in a chromosomal rearrangement and fusion with MECT1 in mucoepidermoid carcinomas, secondary acute myeloid leukemia, hidradenomas, and myelodysplastic syndrome. MECT1 is a CREB regulator, and when fused with the transactivational domain of MAML2, imparts constitutive activation of CREB-dependent transcription that may promote oncogenesis.

Gen-ID: 84441

UniProt: Q8IZL2