MAML2 Antikörper (AA 750-850)

Produktnummer ABIN7268410

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch MAML2 in WB und IF. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für MAML2 Antikörper (AA 750-850) (ABIN7268410)

Target: MAML2 (Mastermind-Like 2 (MAML2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MAML2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF)

Produktdetails anti-MAML2 Antikörper

Bindungsspezifität: AA 750-850

Verwendungszweck: MAML2 Rabbit pAb

Sequenz: NQQLMGKKQT LQRQIMEQKQ QLLLQQQMLA DAEKIAPQDQ INRHLSRPPP DYKDQRRNVG NMQPTAQYSG GSSTISLNSN QALANPVSTH TILTPNSSLL S

Kreuzreaktivität: Human, Maus, Ratte

Produktmerkmale: Polyclonal Antibodies

Aufreinigung: Affinity purification

Immunogen: A synthetic peptide corresponding to a sequence within amino acids 750-850 of human MAML2 (NP_115803.1).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:2000,IF,1:50 - 1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu MAML2

Target: MAML2 (Mastermind-Like 2 (MAML2))

Andere Bezeichnung: MAML2

Hintergrund: The protein encoded by this gene is a member of the Mastermind-like family of proteins. All family members are proline and glutamine-rich, and contain a conserved basic domain that binds the ankyrin repeat domain of the intracellular domain of the Notch receptors (ICN1-4) in their N-terminus, and a transcriptional activation domain in their C-terminus. This protein binds to an extended groove that is formed by the interaction of CBF1, Suppressor of Hairless, LAG-1 (CSL) with ICN, and positively regulates Notch signaling. High levels of expression of this gene have been observed in several B cell-derived lymphomas. Translocations resulting in fusion proteins with both CRTC1 and CRTC3 have been implicated in the development of mucoepidermoid carcinomas, while a translocation event with CXCR4 has been linked with chronic lymphocytic leukemia (CLL). Copy number variation in the polyglutamine tract has been observed.,MAML2,MAM-3,MAM2,MAM3,MLL-MAML2,Epigenetics & Nuclear Signaling,Signal Transduction,Cell Biology & Developmental Biology,Notch Signaling Pathway,Stem Cells,MAML2

Gen-ID: 84441

UniProt: Q8IZL2