MAML2 Antikörper (C-Term)
Kurzübersicht für MAML2 Antikörper (C-Term) (ABIN7454661)
Target
Alle MAML2 Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
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Bindungsspezifität
- C-Term
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Verwendungszweck
- Rabbit anti-MAML2 Antibody, Affinity Purified
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Homologie
- Bovine
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Aufreinigung
- Affinity Purified
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Immunogen
- between AA 1100 and C-term
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Isotyp
- IgG
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Applikationshinweise
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IHC: 1:200 - 1:1,000. Epitope retrieval with Tris-EDTA pH 9.0 is recommended for FFPE tissue sections.
IP: 1 - 4 μg/mg lysate
WB: 1:2,000 - 1:15,000
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Konzentration
- 200 μg/mL
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Buffer
- Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide
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Konservierungsmittel
- Sodium azide
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Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Lagerung
- 4 °C
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Haltbarkeit
- 12 months
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- MAML2 (Mastermind-Like 2 (MAML2))
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Andere Bezeichnung
- MAML2
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Hintergrund
- Background: There are 3 MAML (mastermind-like) proteins in mammals (MAML1-3). MAML2 is a critical coactivator for NOTCH signaling. MAML2 associates with NOTCH and CSL in a ternary complex and functions to activate transcription of HES and hairy-related basic helix-loop-helix transcription factors. MAML2 has been identified in a chromosomal rearrangement and fusion with MECT1 in mucoepidermoid carcinomas, secondary acute myeloid leukemia, hidradenomas, and myelodysplastic syndrome. MECT1 is a CREB regulator, and when fused with the transactivational domain of MAML2, imparts constitutive activation of CREB-dependent transcription that may promote oncogenesis.
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Gen-ID
- 84441
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UniProt
- Q8IZL2
Target
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