WWOX Antikörper (AA 364-414)

Produktnummer ABIN7454501

Dieses Anti-WWOX-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von WWOX in IP und IHC (fp). Geeignet für Human.

Kurzübersicht für WWOX Antikörper (AA 364-414) (ABIN7454501)

Target: WWOX (WW Domain Containing Oxidoreductase (WWOX))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser WWOX Antikörper ist unkonjugiert

Applikation: Immunoprecipitation (IP), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Produktdetails anti-WWOX Antikörper

Bindungsspezifität: AA 364-414

Verwendungszweck: Rabbit anti-WWOX Antibody, Affinity Purified

Homologie: Orangutan

Aufreinigung: Affinity Purified

Immunogen: Between AA 364 and 414

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

IHC: 1:500 - 1:2,000. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

IP: 2 - 10 μg/mg lysate

WB: Not recommended. A304-079A has not performed satisfactorily when used for WB of WWOX in crude preparations (e.g. whole cell lysate). This antibody can be used for WB of enriched (e.g. immunoprecipitated) sources of WWOX.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Haltbarkeit: 12 months

Details zu WWOX

Target: WWOX (WW Domain Containing Oxidoreductase (WWOX))

Andere Bezeichnung: WWOX

Hintergrund: Background: WW domain-containing oxidoreductase (WWOX) is a putative oxidoreductase, acts as a tumor suppressor, plays a role in apoptosis, and is required for normal bone development (by similarity). WWOX may function synergistically with p53/TP53 to control genotoxic stress-induced cell death. It plays a role in TGFB1 signaling and TGFB1-mediated cell death and may also play a role in tumor necrosis factor (TNF)-mediated cell death. WWOX inhibits Wnt signaling, probably by sequestering DVL2 in the cytoplasm [taken from the Universal Protein Resource (UniProt) Q9NZC7].

Gen-ID: 51741

UniProt: Q9NZC7