WWOX Antikörper (AA 1-245)

Produktnummer ABIN5693294

Produktdetails anti-WWOX Antikörper

Target: WWOX (WW Domain Containing Oxidoreductase (WWOX))

Bindungsspezifität: AA 1-245

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser WWOX Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Marke: Picoband™

Kreuzreaktivität (Details): No cross reactivity with other proteins.

Produktmerkmale: Rabbit IgG polyclonal antibody for WWOX detection. Tested with WB, IHC-P, Direct ELISA in Human,Mouse,Rat.

Immunogen: E. coli-derived human WWOX recombinant protein (Position: M1-D245).

Anwendungsinformationen

Applikationshinweise:

Recommended Detection Systems: Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ABIN921124) for Western blot, and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (SV0002-1) for IHC(P).

Application Details: Western blot, 0.1-0.5 μg/mL
Immunohistochemistry(Paraffin-embedded Section), 0.5-1 μg/mL
Direct ELISA, 0.1-0.5 μg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na₂HPO₄, 0.05 mg NaN₃.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for a longer time. Avoid repeated freezing and thawing.

Details zu WWOX

Target: WWOX (WW Domain Containing Oxidoreductase (WWOX))

Andere Bezeichnung: WWOX (WWOX Produkte)

Synonyme: CG7221 antikoerper, DmWWOX antikoerper, Dmel\\CG7221 antikoerper, anon-EST:Posey177 antikoerper, GB11795 antikoerper, WWOX antikoerper, D16S432E antikoerper, FOR antikoerper, FRA16D antikoerper, HHCMA56 antikoerper, PRO0128 antikoerper, SDR41C1 antikoerper, WOX1 antikoerper, zgc:55975 antikoerper, 5330426P09Rik antikoerper, 9030416C10Rik antikoerper, WW domain containing oxidoreductase antikoerper, WW domain-containing oxidoreductase antikoerper, Wwox antikoerper, LOC411815 antikoerper, WWOX antikoerper, CpipJ_CPIJ004939 antikoerper, MCYG_01584 antikoerper, VDBG_05631 antikoerper, VDBG_01326 antikoerper, VDBG_06753 antikoerper, Tsp_03967 antikoerper, LOC100284583 antikoerper, wwox antikoerper

Hintergrund:

Synonyms: WW domain-containing oxidoreductase, Fragile site FRA16D oxidoreductase, Short chain dehydrogenase/reductase family 41C member 1, WWOX, FOR, SDR41C1, WOX1

Tissue Specificity: Widely expressed. Strongly expressed in testis, prostate, and ovary. Overexpressed in cancer cell lines. Isoform 5 and isoform 6 may only be expressed in tumor cell lines.

Background: WW domain-containing oxidoreductase is an enzyme that in humans is encoded by the WWOX gene. This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) protein family. It spans the FRA16D common chromosomal fragile site and appears to function as a tumor suppressor gene. Expression of the encoded protein is able to induce apoptosis, while defects in this gene are associated with multiple types of cancer. Disruption of this gene is also associated with autosomal recessive spinocerebellar ataxia 12. Disruption of a similar gene in mouse results in impaired steroidogenesis, additionally suggesting a metabolic function for the protein. Alternative splicing results in multiple transcript variants.