Desmoplakin Antikörper (AA 1900-1950)
Kurzübersicht für Desmoplakin Antikörper (AA 1900-1950) (ABIN7454486)
Target
Alle Desmoplakin (DSP) Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
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Bindungsspezifität
- AA 1900-1950
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Verwendungszweck
- Rabbit anti-Desmoplakin Antibody, Affinity Purified
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Aufreinigung
- Affinity Purified
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Immunogen
- between AA 1900 and 1950
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Isotyp
- IgG
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Applikationshinweise
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IHC: 1:500 - 1:2,000. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.
IP: 2 - 10 μg/mg lysate
WB: Not recommended
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Konzentration
- 1000 μg/mL
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Buffer
- Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide
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Konservierungsmittel
- Sodium azide
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Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Lagerung
- 4 °C
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Haltbarkeit
- 12 months
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- Desmoplakin (DSP)
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Andere Bezeichnung
- Desmoplakin
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Hintergrund
- Background: Desmosomes are intercellular junctions that tightly link adjacent cells. Desmoplakin is an obligate component of functional desmosomes that anchors intermediate filaments to desmosomal plaques. The N-terminus of desmoplakin is required for localization to the desmosome and interacts with the N-terminal region of plakophilin 1 and plakoglobin. The C-terminus of desmoplakin binds with intermediate filaments. In the mid-region of desmoplakin, a coiled-coiled rod domain is responsible for homodimerization. Mutations in DSP, the gene encoding desmoplakin, are the cause of several cardiomyopathies and keratodermas as well as the autoimmune disease paraneoplastic pemphigus [taken from NCBI Entrez Gene (Gene ID: 1832)].
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Gen-ID
- 1832
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NCBI Accession
- NP_004406
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UniProt
- P15924
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Pathways
- Cell-Cell Junction Organization
Target
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