PRCC Antikörper (AA 125-175)

Produktnummer ABIN7454446

Der Kaninchen Polyklonal anti-PRCC Antikörper wird verwendet zum Nachweis von PRCC in Proben von Human. Er wurde validiert für IP und IHC (fp).

Kurzübersicht für PRCC Antikörper (AA 125-175) (ABIN7454446)

Target: PRCC (Papillary Renal Cell Carcinoma (Translocation-Associated) (PRCC))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PRCC Antikörper ist unkonjugiert

Applikation: Immunoprecipitation (IP), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Produktdetails anti-PRCC Antikörper

Bindungsspezifität: AA 125-175

Verwendungszweck: Rabbit anti-PRCC Antibody, Affinity Purified

Aufreinigung: Affinity Purified

Immunogen: between AA 125 and 175

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

IHC: 1:500 - 1:2,000. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

IP: 2 - 5 μg/mg lysate

WB: Not recommended. Use rabbit anti-PRCC antibody A302-340A.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Haltbarkeit: 12 months

Details zu PRCC

Target: PRCC (Papillary Renal Cell Carcinoma (Translocation-Associated) (PRCC))

Andere Bezeichnung: PRCC

Hintergrund: Background: In a subset of papillary renal cell carcinomas, a t(X,1)(p11,q21) chromosome translocation has been repeatedly reported and is thought to be the cause of the cancer. As a result of the translocation, the transcription factor TFE3 on the X chromosome becomes fused to the PRCC (papillary renal cell carcinoma translocation-associated) gene on chromosome 1. The fused gene results in the fusion of N-terminal proline-rich region of the protein encoded by this gene to the entire TFE3 protein. This protein has been shown to interact with the mitotic checkpoint protein MAD2B, which suggests that the dominant-negative effect of the fusion protein with TFE3 may lead to a mitotic checkpoint defect [taken from NCBI GeneID:5546].

Gen-ID: 5546

NCBI Accession: NP_005964

UniProt: Q92733