PRCC Antikörper (AA 425-475)

Produktnummer ABIN7451980

Produktdetails anti-PRCC Antikörper

Target: PRCC (Papillary Renal Cell Carcinoma (Translocation-Associated) (PRCC))

Bindungsspezifität: AA 425-475

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PRCC Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunoprecipitation (IP)

Verwendungszweck: Rabbit anti-PRCC Antibody, Affinity Purified

Aufreinigung: Affinity Purified

Immunogen: between AA 425 and 475

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

IP: 2 - 5 μg/mg lysate

WB: 1:2,000 - 1:10,000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Haltbarkeit: 12 months

Details zu PRCC

Target: PRCC (Papillary Renal Cell Carcinoma (Translocation-Associated) (PRCC))

Andere Bezeichnung: PRCC (PRCC Produkte)

Synonyme: tprc antikoerper, XPrcc antikoerper, rccp1 antikoerper, RCCP1 antikoerper, TPRC antikoerper, papillary renal cell carcinoma (translocation-associated) antikoerper, PRCC antikoerper, prcc antikoerper, Prcc antikoerper

Hintergrund: Background: In a subset of papillary renal cell carcinomas, a t(X,1)(p11,q21) chromosome translocation has been repeatedly reported and is thought to be the cause of the cancer. As a result of the translocation, the transcription factor TFE3 on the X chromosome becomes fused to the PRCC (papillary renal cell carcinoma translocation-associated) gene on chromosome 1. The fused gene results in the fusion of N-terminal proline-rich region of the protein encoded by this gene to the entire TFE3 protein. This protein has been shown to interact with the mitotic checkpoint protein MAD2B, which suggests that the dominant-negative effect of the fusion protein with TFE3 may lead to a mitotic checkpoint defect [taken from NCBI GeneID:5546].

Gen-ID: 5546

NCBI Accession: NP_005964

UniProt: Q92733