Rekombinanter Polybromo 1 Antikörper (AA 1-293)

Produktnummer ABIN7454032

Der Kaninchen Monoklonal Anti-Polybromo 1-Antikörper wurde für WB, IHC, IP, ICC, FACS und IF (p) validiert. Er ist geeignet, Polybromo 1 in Proben von Human und Maus zu detektieren.

Kurzübersicht für Rekombinanter Polybromo 1 Antikörper (AA 1-293) (ABIN7454032)

Target: Polybromo 1 (PBRM1)

Antikörpertyp: Recombinant Antibody

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser Polybromo 1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunocytochemistry (ICC), Flow Cytometry (FACS), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Klon: BL-39-2C3

Produktdetails anti-Polybromo 1 Antikörper

Bindungsspezifität: AA 1-293

Verwendungszweck: Rabbit anti-PBRM1 Recombinant Monoclonal Antibody [BL-39-2C3]

Immunogen: residues 1-293

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1000 μg/mL

Buffer: Borate Buffered Saline (BBS) pH 8.2 with 0.09 % Sodium Azide, BSA-Free

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Haltbarkeit: 12 months

Details zu Polybromo 1

Target: Polybromo 1 (PBRM1)

Andere Bezeichnung: PBRM1

Hintergrund: Background: The SMARCs (SWI/SNF-related, matrix-associated, actin-dependent regulators of chromatin), and BAFs (BRG1-associated factors), have been identified as components of the mammalian SWI/SNF-like chromatin-remodeling protein complexes. These multi-protein complexes are proposed to function as ATP-driven motors that translocate along DNA and destabilize nucleosomal structures to facilitate transcription factor binding. PBRM1 is a component of the SWI/SNF-B (PBAF) complex. It contains six bromodomains which are defined by a 110 amino-acid module that interacts with acetylated lysine and is found in many chromatin binding proteins and histone acetyltransferases. PBRM1 has been proposed to function as a tumor suppressor protein. Recently, PBRM1 has been found to play a role in mediating cell cycle arrest in response to DNA damage via the regulation of the tumor suppressor p21.

Gen-ID: 55193

UniProt: Q86U86