NUMA1 Antikörper (AA 2065-2115)

Produktnummer ABIN7453748

Der Kaninchen Polyklonal Anti-NUMA1-Antikörper wurde für WB, IP und IHC (fp) validiert. Er ist geeignet, NUMA1 in Proben von Human zu detektieren.

Kurzübersicht für NUMA1 Antikörper (AA 2065-2115) (ABIN7453748)

Target: NUMA1 (Nuclear Mitotic Apparatus Protein 1 (NUMA1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NUMA1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Produktdetails anti-NUMA1 Antikörper

Bindungsspezifität: AA 2065-2115

Verwendungszweck: Rabbit anti-NUMA Antibody, Affinity Purified

Aufreinigung: Affinity Purified

Immunogen: between AA 2065 and 2115

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

IHC: 1:100 - 1:500. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

IP: 2 - 5 μg/mg lysate

WB: 1:2,000 - 1:10,000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 200 μg/mL

Buffer: Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Haltbarkeit: 12 months

Details zu NUMA1

Target: NUMA1 (Nuclear Mitotic Apparatus Protein 1 (NUMA1))

Andere Bezeichnung: NUMA

Hintergrund: Background: The nuclear mitotic apparatus protein (NuMA) is a critical component of the mitotic spindle that is responsible for organizing minus-ends of microtubules at spindle poles. NUMA is regulated by phosphorylation and associates with dynein and dynactin in its phosphorylated form. Dephosphorylation of NUMA in anaphase results in the release from dynein and dynactin to allow spindle disassembly. NUMA, in association with dynein and dynactin, also interacts with 4.1R in a complex of spindle pole organizing proteins. Other NUMA interacting proteins include GAS41, tankyrase, and Rae1. These interactions indicate a broader role for NUMA function in the nucleus.

Gen-ID: 4926

NCBI Accession: NP_006176

UniProt: Q14980

Pathways: Caspase Kaskade in der Apoptose, Regulation of Actin Filament Polymerization, M Phase