UIMC1 Antikörper (C-Term)

Produktnummer ABIN7453599

Dieses Anti-UIMC1-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von UIMC1 in WB, IP und IHC (fp). Geeignet für Human.

Kurzübersicht für UIMC1 Antikörper (C-Term) (ABIN7453599)

Target: UIMC1 (Ubiquitin Interaction Motif Containing 1 (UIMC1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser UIMC1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Produktdetails anti-UIMC1 Antikörper

Bindungsspezifität: C-Term

Verwendungszweck: Rabbit anti-RAP80 Antibody, Affinity Purified

Aufreinigung: Affinity Purified

Immunogen: between AA 650 and C-term

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

IHC: 1:1,000 to 1:5,000. Epitope retrieval with Tris-EDTA pH 9.0 is recommended for FFPE tissue sections.

IP: 2 -10 μg/mg lysate

WB: 1:10,000 - 1:25,000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Haltbarkeit: 12 months

Details zu UIMC1

Target: UIMC1 (Ubiquitin Interaction Motif Containing 1 (UIMC1))

Andere Bezeichnung: RAP80

Hintergrund: Background: RAP80 was first identified as a nuclear protein that interacts with the retinoid-related testis-associated receptor (RTR) and is able to inhibit the interaction of RTR with the N-CoR co-repressor. RAP80 has also been shown to interact with estrogen receptor alpha (ER-alpha) and modulate its activity. The modulation of ER-alpha activity is dependent on the ubiquitin-interacting motif (UIM) of RAP80. The UIM of RAP80 has also been demonstrated to be important for the BRCA1-dependent DNA repair response.

Gen-ID: 51720

NCBI Accession: NP_057374

UniProt: Q96RL1

Pathways: DNA Reparatur, Nuclear Hormone Receptor Binding, Positive Regulation of Response to DNA Damage Stimulus