Geminin Antikörper (C-Term)
Kurzübersicht für Geminin Antikörper (C-Term) (ABIN7453481)
Target
Alle Geminin (GMNN) Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
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Bindungsspezifität
- C-Term
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Verwendungszweck
- Rabbit anti-Geminin Antibody, Affinity Purified
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Aufreinigung
- Affinity Purified
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Immunogen
- between AA 160 and C-term
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Isotyp
- IgG
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Applikationshinweise
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IHC: 1:1,000 - 1:5,000. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.
IP: 2 - 5 μg/mg lysate
WB: 1:2,000 - 1:10,000
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Konzentration
- 1000 μg/mL
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Buffer
- Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide
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Konservierungsmittel
- Sodium azide
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Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Lagerung
- 4 °C
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Haltbarkeit
- 12 months
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- Geminin (GMNN) (Geminin, DNA Replication Inhibitor (GMNN))
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Andere Bezeichnung
- Geminin
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Hintergrund
- Background: Geminin has been identified as a protein that inhibits DNA replication during S, G2, and M phases in association with Cdt1 (chromatin licensing and DNA replication factor). Geminin prevents the binding of the MCM complex onto origins of replication, and its abundance is regulated by ubiquitin ligase activity of the APC/C (anaphase-promoting/cyclosome) complex.
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Gen-ID
- 51053
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NCBI Accession
- NP_056979
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UniProt
- O75496
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Pathways
- EGFR Signaling Pathway, DNA Replication
Target
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