SRRT Antikörper (AA 826-876)

Produktnummer ABIN7453421

Der Kaninchen Polyklonal Anti-SRRT-Antikörper wurde für WB, IP und IHC (fp) validiert. Er ist geeignet, SRRT in Proben von Human und Maus zu detektieren.

Kurzübersicht für SRRT Antikörper (AA 826-876) (ABIN7453421)

Target: SRRT (Serrate RNA Effector Molecule Homolog (SRRT))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SRRT Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Produktdetails anti-SRRT Antikörper

Bindungsspezifität: AA 826-876

Verwendungszweck: Rabbit anti-ARS2 Antibody, Affinity Purified

Homologie: Zebrafish,X. laevis,Bovine,Orangutan

Aufreinigung: Affinity Purified

Immunogen: Between AA 826 and 876

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

IHC: 1:1,000 - 1:5,000. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

IP: 2 - 10 μg/mg lysate

WB: 1:2,000 - 1:10,000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Haltbarkeit: 12 months

Details zu SRRT

Target: SRRT (Serrate RNA Effector Molecule Homolog (SRRT))

Andere Bezeichnung: ARS2

Hintergrund: Background: Arsenate resistance protein 2 (ARS2) acts as a mediator between the cap-binding complex (CBC) and the primary microRNAs (miRNAs) processing machinery during cell proliferation. ARS2 contributes to the stability and delivery of capped primary miRNA transcripts to the primary miRNA processing complex containing DGCR8 and DROSHA, thereby playing a role in RNA-mediated gene silencing (RNAi) by miRNAs. ARS2 does not directly confer arsenite resistance but rather modulates arsenic sensitivity. Independently of its activity on miRNAs, it is necessary and sufficient to promote neural stem cell self-renewa and does so by directly binding SOX2 promoter and positively regulating its transcription (By similarity) [taken from the Universal Protein Resource (UniProt) Q9BXP5].

Gen-ID: 51593

NCBI Accession: NP_056992

UniProt: Q9BXP5

Pathways: Notch Signalweg, Stem Cell Maintenance